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Venom factor

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Complement-activating protein in venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex VF/Bb. VF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, VF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, VF continuously activates complement resulting in the depletion of complement activity (By similarity).

Below are the list of possible Venom factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Venom factor

 Venom factor ELISA Kit
 Venom factor Recombinant
 Venom factor Antibody
Also known as Venom factor (VF) (CVF-like) (Complement C3 homolog).
Complement-activating protein in venom. It is a structural and functional analog of complement component C3b, the activated form
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of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex VF/Bb. VF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, VF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, VF continuously activates complement resulting in the depletion of complement activity ().
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