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Promotes up-regulation of actin stress fiber formation.

Below are the list of possible Vinexin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.


 Vinexin ELISA Kit
 Vinexin Recombinant
 Vinexin Antibody
Also known as Vinexin (SH3 domain-containing protein SH3P3) (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3).
vinexin: an adapter protein that contains three SH3 domains and is involved in the reorganization of actin cytoskeleton. Two alternatively spliced isoforms have been described. Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain. Both isoforms localize at focal adhes
ion and cell-cell adhesion sites; vinexin beta was also found in the nucleus. Interacts with DLG5 through its third SH3 domain. Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC) through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with SAFB2.

Protein type: Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator

Cellular Component: cytoplasm; focal adhesion; nucleus

Molecular Function: protein binding; transcription factor binding; vinculin binding

Biological Process: cell-substrate adhesion; negative regulation of transcription from RNA polymerase II promoter; positive regulation of MAPKKK cascade; positive regulation of stress fiber formation
 Sorbs3 ELISA Kit
 Sorbs3 Recombinant
 Sorbs3 Antibody
 Scam1 ELISA Kit
 Scam1 Recombinant
 Scam1 Antibody
 Sh3d4 ELISA Kit
 Sh3d4 Recombinant
 Sh3d4 Antibody
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