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Voltage-dependent L-type calcium channel

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Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.

Below are the list of possible Voltage-dependent L-type calcium channel products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Voltage-dependent L-type calcium channel subunit alpha-1C

 Voltage-dependent L-type calcium channel subunit alpha-1C ELISA Kit
 Voltage-dependent L-type calcium channel subunit alpha-1C Recombinant
 Voltage-dependent L-type calcium channel subunit alpha-1C Antibody
Also known as Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (MELC-CC) (Mouse brain class C) (MBC) (Voltage-gated calcium channel subunit alpha Cav1.2).
CACNA1C: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium current
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s. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function. Defects in CACNA1C are the cause of Timothy syndrome (TS). TS is a disorder characterized by multiorgan dysfunction including lethal arrhythmias, webbing of fingers and toes, congenital heart disease, immune deficiency, intermittent hypoglycemia, cognitive abnormalities and autism. Defects in CACNA1C are the cause of Brugada syndrome type 3 (BRGDA3). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily. 35 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: caveolar macromolecular signaling complex; cell soma; cytoplasm; dendrite; dendritic shaft; integral to membrane; membrane; plasma membrane; postsynaptic density; protein complex; sarcolemma; T-tubule; voltage-gated calcium channel complex; Z disc

Molecular Function: alpha-actinin binding; calmodulin binding; enzyme binding; high voltage-gated calcium channel activity; protein binding; protein domain specific binding; protein phosphatase 2A binding; translation initiation factor binding; voltage-gated calcium channel activity

Biological Process: adult walking behavior; calcium ion transport; calcium ion-dependent exocytosis; camera-type eye development; cellular calcium ion homeostasis; elevation of cytosolic calcium ion concentration; embryonic forelimb morphogenesis; glucose homeostasis; growth hormone secretion; heart development; immune system development; insulin secretion; regulation of blood pressure; regulation of organ growth; regulation of vasoconstriction; smooth muscle contraction; smooth muscle contraction involved in micturition; synaptic transmission; visual learning
 Cacna1c ELISA Kit
 Cacna1c Recombinant
 Cacna1c Antibody
 Cach2 ELISA Kit
 Cach2 Recombinant
 Cach2 Antibody
 Cacn2 ELISA Kit
 Cacn2 Recombinant
 Cacn2 Antibody
 Cacnl1a1 ELISA Kit
 Cacnl1a1 Recombinant
 Cacnl1a1 Antibody
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Voltage-dependent L-type calcium channel subunit alpha-1D

 Voltage-dependent L-type calcium channel subunit alpha-1D ELISA Kit
 Voltage-dependent L-type calcium channel subunit alpha-1D Recombinant
 Voltage-dependent L-type calcium channel subunit alpha-1D Antibody
Also known as Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide isoform 2) (Voltage-gated calcium channel subunit alpha Cav1.3).
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-vo
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ltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
 CACNA1D ELISA Kit
 CACNA1D Recombinant
 CACNA1D Antibody
 CACH3 ELISA Kit
 CACH3 Recombinant
 CACH3 Antibody
 CACN4 ELISA Kit
 CACN4 Recombinant
 CACN4 Antibody
 CACNL1A2 ELISA Kit
 CACNL1A2 Recombinant
 CACNL1A2 Antibody
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Voltage-dependent L-type calcium channel subunit alpha-1F

 Voltage-dependent L-type calcium channel subunit alpha-1F ELISA Kit
 Voltage-dependent L-type calcium channel subunit alpha-1F Recombinant
 Voltage-dependent L-type calcium channel subunit alpha-1F Antibody
Also known as Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage-gated calcium channel subunit alpha Cav1.4).
CACNA1F: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility,
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cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Defects in CACNA1F are the cause of congenital stationary night blindness type 2A (CSNB2A). Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. Defects in CACNA1F are the cause of cone-rod dystrophy X- linked type 3 (CORDX3). CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. Defects in CACNA1F are the cause of Aaland island eye disease (AIED); also known as Forsius-Eriksson type ocular albinism. On the Aaland island in the Baltic Sea, AIED is an X-linked recessive retinal disease characterized by a combination of fundus hypopigmentation, decreased visual acuity due to foveal hypoplasia, nystagmus, astigmatism, protan color vision defect, myopia, and defective dark adaptation. Except for progression of axial myopia, the disease can be considered to be a stationary condition. Electroretinography reveals abnormalities in both photopic and scotopic functions. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1F subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: cell soma; integral to membrane; membrane; perikaryon; photoreceptor outer segment; plasma membrane; voltage-gated calcium channel complex

Molecular Function: high voltage-gated calcium channel activity; voltage-gated calcium channel activity

Biological Process: axonogenesis; cellular calcium ion homeostasis; dendrite morphogenesis; detection of light stimulus involved in visual perception; retina development in camera-type eye; visual perception
 Cacna1f ELISA Kit
 Cacna1f Recombinant
 Cacna1f Antibody
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Voltage-dependent L-type calcium channel subunit alpha-1S

 Voltage-dependent L-type calcium channel subunit alpha-1S ELISA Kit
 Voltage-dependent L-type calcium channel subunit alpha-1S Recombinant
 Voltage-dependent L-type calcium channel subunit alpha-1S Antibody
Also known as Voltage-dependent L-type calcium channel subunit alpha-1S (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle) (ROB1) (Voltage-gated calcium channel subunit alpha Cav1.1).
CACNA1S: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calci
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um channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle

Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: cytoplasm; I band; plasma membrane; sarcolemma; sarcoplasmic reticulum; T-tubule; voltage-gated calcium channel complex

Molecular Function: high voltage-gated calcium channel activity; voltage-gated calcium channel activity

Biological Process: calcium ion transport; endoplasmic reticulum organization and biogenesis; extraocular skeletal muscle development; muscle cell development; muscle contraction; myoblast fusion; neuromuscular junction development; skeletal development; skeletal muscle adaptation; skeletal muscle development; skeletal muscle fiber development; striated muscle contraction
 Cacna1s ELISA Kit
 Cacna1s Recombinant
 Cacna1s Antibody
 Cach1 ELISA Kit
 Cach1 Recombinant
 Cach1 Antibody
 Cacn1 ELISA Kit
 Cacn1 Recombinant
 Cacn1 Antibody
 Cacnl1a3 ELISA Kit
 Cacnl1a3 Recombinant
 Cacnl1a3 Antibody
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Voltage-dependent L-type calcium channel subunit beta-1

 Voltage-dependent L-type calcium channel subunit beta-1 ELISA Kit
 Voltage-dependent L-type calcium channel subunit beta-1 Recombinant
 Voltage-dependent L-type calcium channel subunit beta-1 Antibody
Also known as Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).
CACNB1: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the
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alpha-1 subunit membrane targeting. Belongs to the calcium channel beta subunit family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium

Chromosomal Location of Human Ortholog: 17q21-q22

Cellular Component: plasma membrane

Molecular Function: high voltage-gated calcium channel activity; voltage-gated calcium channel activity

Biological Process: neuromuscular junction development; synaptic transmission; transport
 CACNB1 ELISA Kit
 CACNB1 Recombinant
 CACNB1 Antibody
 CACNLB1 ELISA Kit
 CACNLB1 Recombinant
 CACNLB1 Antibody
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Voltage-dependent L-type calcium channel subunit beta-2

 Voltage-dependent L-type calcium channel subunit beta-2 ELISA Kit
 Voltage-dependent L-type calcium channel subunit beta-2 Recombinant
 Voltage-dependent L-type calcium channel subunit beta-2 Antibody
Also known as Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2).
CACNB2: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the
>>>
alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRGDA4). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel beta subunit family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium

Cellular Component: voltage-gated calcium channel complex

Molecular Function: actin filament binding; calcium channel regulator activity; high voltage-gated calcium channel activity; phosphoprotein binding; protein binding; protein domain specific binding; protein kinase binding; voltage-gated calcium channel activity

Biological Process: calcium ion transport; neuromuscular junction development; positive regulation of calcium ion transport; synaptic transmission; visual perception
 Cacnb2 ELISA Kit
 Cacnb2 Recombinant
 Cacnb2 Antibody
 Cacnlb2 ELISA Kit
 Cacnlb2 Recombinant
 Cacnlb2 Antibody
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Voltage-dependent L-type calcium channel subunit beta-3

 Voltage-dependent L-type calcium channel subunit beta-3 ELISA Kit
 Voltage-dependent L-type calcium channel subunit beta-3 Recombinant
 Voltage-dependent L-type calcium channel subunit beta-3 Antibody
Also known as Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3).
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1
>>>
subunit membrane targeting.
 CACNB3 ELISA Kit
 CACNB3 Recombinant
 CACNB3 Antibody
 CACNLB3 ELISA Kit
 CACNLB3 Recombinant
 CACNLB3 Antibody
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Voltage-dependent L-type calcium channel subunit beta-4

 Voltage-dependent L-type calcium channel subunit beta-4 ELISA Kit
 Voltage-dependent L-type calcium channel subunit beta-4 Recombinant
 Voltage-dependent L-type calcium channel subunit beta-4 Antibody
Also known as Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).
CACNB4: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the
>>>
alpha-1 subunit membrane targeting. Defects in CACNB4 are the cause of susceptibility to epilepsy, idiopathic generalized type 9 (EIG9). A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Defects in CACNB4 are the cause of susceptibility to juvenile myoclonic epilepsy type 6 (EJM6). EJM6 is a subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Defects in CACNB4 are the cause of episodic ataxia type 5 (EA5). EA5 is a disorder characterized by episodes of vertigo and ataxia that last for several hours. Interictal examination show spontaneous downbeat and gaze-evoked nystagmus, mild dysarthria and truncal ataxia. Belongs to the calcium channel beta subunit family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium

Cellular Component: voltage-gated calcium channel complex

Molecular Function: high voltage-gated calcium channel activity; protein binding; protein kinase binding; voltage-gated calcium channel activity

Biological Process: action potential propagation; adult walking behavior; calcium ion transport; cAMP metabolic process; cellular calcium ion homeostasis; detection of light stimulus involved in visual perception; gamma-aminobutyric acid secretion; gamma-aminobutyric acid signaling pathway; muscle fiber development; neurological system process; neuromuscular junction development; Peyer's patch development; regulation of membrane potential; spleen development; synaptic transmission, GABAergic; synaptic transmission, glutamatergic; T cell differentiation; T cell receptor signaling pathway; thymus development
 Cacnb4 ELISA Kit
 Cacnb4 Recombinant
 Cacnb4 Antibody
 Cacnlb4 ELISA Kit
 Cacnlb4 Recombinant
 Cacnlb4 Antibody
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