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Voltage-dependent P/Q-type calcium channel

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Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).

Below are the list of possible Voltage-dependent P/Q-type calcium channel products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Voltage-dependent P/Q-type calcium channel subunit alpha-1A

 Voltage-dependent P/Q-type calcium channel subunit alpha-1A ELISA Kit
 Voltage-dependent P/Q-type calcium channel subunit alpha-1A Recombinant
 Voltage-dependent P/Q-type calcium channel subunit alpha-1A Antibody
Also known as Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Brain calcium channel I) (BI) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Voltage-gated calcium channel subunit alpha Cav2.1).
CACNA1A: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type c
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alcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA). Defects in CACNA1A are the cause of spinocerebellar ataxia type 6 (SCA6). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA6 is mainly caused by expansion of a CAG repeat in the coding region of CACNA1A. There seems to be a correlation between the repeat number and earlier onset of the disorder. Defects in CACNA1A are the cause of familial hemiplegic migraine type 1 (FHM1); also known as migraine familial hemiplegic 1 (MHP1). FHM1, a rare autosomal dominant subtype of migraine with aura, is associated with ictal hemiparesis and, in some families, progressive cerebellar atrophy. Defects in CACNA1A are the cause of episodic ataxia type 2 (EA2); also known as acetazolamide-responsive hereditary paroxysmal cerebellar ataxia (APCA). EA2 is an autosomal dominant disorder characterized by acetozolamide- responsive attacks of ataxia, migraine-like symptoms, interictal nystagmus, and cerebellar atrophy. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19p13

Cellular Component: cell projection; cytoplasm; integral to membrane; nucleus; plasma membrane

Molecular Function: calcium channel activity; high voltage-gated calcium channel activity; protein binding; syntaxin binding; voltage-gated calcium channel activity

Biological Process: cell death; elevation of cytosolic calcium ion concentration; membrane depolarization; regulation of insulin secretion

Disease: Epileptic Encephalopathy, Early Infantile, 42; Episodic Ataxia, Type 2; Migraine, Familial Hemiplegic, 1; Spinocerebellar Ataxia 6
 CACNA1A ELISA Kit
 CACNA1A Recombinant
 CACNA1A Antibody
 CACH4 ELISA Kit
 CACH4 Recombinant
 CACH4 Antibody
 CACN3 ELISA Kit
 CACN3 Recombinant
 CACN3 Antibody
 CACNL1A4 ELISA Kit
 CACNL1A4 Recombinant
 CACNL1A4 Antibody
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