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Voltage-dependent T-type calcium channel

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Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

Below are the list of possible Voltage-dependent T-type calcium channel products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Voltage-dependent T-type calcium channel subunit alpha-1G

 Voltage-dependent T-type calcium channel subunit alpha-1G ELISA Kit
 Voltage-dependent T-type calcium channel subunit alpha-1G Recombinant
 Voltage-dependent T-type calcium channel subunit alpha-1G Antibody
Also known as Voltage-dependent T-type calcium channel subunit alpha-1G (Cav3.1c) (NBR13) (Voltage-gated calcium channel subunit alpha Cav3.1).
CACNA1G: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expressi
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on, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the low-voltage activated (LVA) group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1G subfamily. 34 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: cytoplasm; plasma membrane; voltage-gated calcium channel complex

Molecular Function: low voltage-gated calcium channel activity

Biological Process: positive regulation of calcium ion-dependent exocytosis; regulation of membrane potential

Disease: Spinocerebellar Ataxia 42
 CACNA1G ELISA Kit
 CACNA1G Recombinant
 CACNA1G Antibody
 KIAA1123 ELISA Kit
 KIAA1123 Recombinant
 KIAA1123 Antibody
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Voltage-dependent T-type calcium channel subunit alpha-1H

 Voltage-dependent T-type calcium channel subunit alpha-1H ELISA Kit
 Voltage-dependent T-type calcium channel subunit alpha-1H Recombinant
 Voltage-dependent T-type calcium channel subunit alpha-1H Antibody
Also known as Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2).
CACNA1H: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone o
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r neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the low-voltage activated (LVA) group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Defects in CACNA1H are a cause of susceptibility to epilepsy, idiopathic generalized type 6 (EIG6). A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. EIG6 is a polygenic and multifactorial disease. Defects in CACNA1H are a cause of susceptibility to epilepsy, childhood absence type 6 (ECA6). A subtype of idiopathic generalized epilepsy characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. Tonic- clonic seizures often develop in adolescence. Absence seizures may either remit or persist into adulthood. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1H subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: integral to membrane

Molecular Function: low voltage-gated calcium channel activity

Biological Process: aldosterone biosynthetic process; cellular response to hormone stimulus; muscle contraction; myoblast fusion; regulation of heart contraction; regulation of membrane potential; transport

Disease: Epilepsy, Childhood Absence, Susceptibility To, 6; Hyperaldosteronism, Familial, Type Iv
 CACNA1H ELISA Kit
 CACNA1H Recombinant
 CACNA1H Antibody
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Voltage-dependent T-type calcium channel subunit alpha-1I

 Voltage-dependent T-type calcium channel subunit alpha-1I ELISA Kit
 Voltage-dependent T-type calcium channel subunit alpha-1I Recombinant
 Voltage-dependent T-type calcium channel subunit alpha-1I Antibody
Also known as Voltage-dependent T-type calcium channel subunit alpha-1I (CaVT.3) (Voltage-gated calcium channel subunit alpha Cav3.3).
CACNA1I: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell
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motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the low-voltage activated (LVA) group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1I subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis

Cellular Component: plasma membrane; voltage-gated calcium channel complex

Molecular Function: low voltage-gated calcium channel activity

Biological Process: generation of action potential; positive regulation of calcium ion-dependent exocytosis; sleep
 Cacna1i ELISA Kit
 Cacna1i Recombinant
 Cacna1i Antibody
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