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Volume-regulated anion channel

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Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition .

Below are the list of possible Volume-regulated anion channel products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Volume-regulated anion channel subunit LRRC8A

 Volume-regulated anion channel subunit LRRC8A ELISA Kit
 Volume-regulated anion channel subunit LRRC8A Recombinant
 Volume-regulated anion channel subunit LRRC8A Antibody
Also known as Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A).
LRRC8A: Involved in B-cell development. Required for the pro-B cell to pre-B cell transition. Defects in LRRC8A are the cause of agammaglobulinemia type 5 (AGM5). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells
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due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. A chromosomal aberration involving LRRC8 has been found in a patient with congenital agammaglobulinemia. Translocation t(9;20)(q33.2;q12). The translocation truncates the LRRC8 gene, resulting in deletion of the eighth, ninth, and half of the seventh LRR domains.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: cell surface; membrane; plasma membrane

Molecular Function: anion channel activity; volume-sensitive anion channel activity

Biological Process: anion transport; cell volume homeostasis; pre-B cell differentiation; response to osmotic stress
 Lrrc8a ELISA Kit
 Lrrc8a Recombinant
 Lrrc8a Antibody
 Lrrc8 ELISA Kit
 Lrrc8 Recombinant
 Lrrc8 Antibody
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Volume-regulated anion channel subunit LRRC8B

 Volume-regulated anion channel subunit LRRC8B ELISA Kit
 Volume-regulated anion channel subunit LRRC8B Recombinant
 Volume-regulated anion channel subunit LRRC8B Antibody
Also known as Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP).
LRRC8B: Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8B constitutes a pore-forming subunit or whether it is closely associated with the pore
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. Belongs to the LRRC8 family. Heterooligomer; heterooligomerizes with other LRRC8 proteins (LRRC8A, LRRC8C, LRRC8D and/or LRRC8E), possibly to form a heterohexamer

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p22.2

Cellular Component: cytoplasm; plasma membrane

Molecular Function: protein binding
 LRRC8B ELISA Kit
 LRRC8B Recombinant
 LRRC8B Antibody
 KIAA0231 ELISA Kit
 KIAA0231 Recombinant
 KIAA0231 Antibody
 UNQ6413/PRO21207 ELISA Kit
 UNQ6413/PRO21207 Recombinant
 UNQ6413/PRO21207 Antibody
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Volume-regulated anion channel subunit LRRC8C

 Volume-regulated anion channel subunit LRRC8C ELISA Kit
 Volume-regulated anion channel subunit LRRC8C Recombinant
 Volume-regulated anion channel subunit LRRC8C Antibody
Also known as Volume-regulated anion channel subunit LRRC8C (Factor for adipocyte differentiation 158) (Leucine-rich repeat-containing protein 8C).
LRRC8C: May play a role in adipogenesis.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p22.2

Cellular Component: cytoplasm; integral to plasma membrane; membrane; plasma membrane

Molecular Function: protein binding; volume-sensitive anion channel activity
 LRRC8C ELISA Kit
 LRRC8C Recombinant
 LRRC8C Antibody
 AD158 ELISA Kit
 AD158 Recombinant
 AD158 Antibody
 FAD158 ELISA Kit
 FAD158 Recombinant
 FAD158 Antibody
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Volume-regulated anion channel subunit LRRC8D

 Volume-regulated anion channel subunit LRRC8D ELISA Kit
 Volume-regulated anion channel subunit LRRC8D Recombinant
 Volume-regulated anion channel subunit LRRC8D Antibody
Also known as Volume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D).
LRRC8D: Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide be
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tter than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8D constitutes a pore-forming subunit or whether it is closely associated with the pore. Mediates the import of the antibiotic blasticidin-S into cell (PubMed:24782309). Belongs to the LRRC8 family. Heterooligomer; heterooligomerizes with other LRRC8 proteins (LRRC8A, LRRC8B, LRRC8C and/or LRRC8E), possibly to form a heterohexamer

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: cytoplasm; integral to plasma membrane; membrane; plasma membrane

Molecular Function: volume-sensitive anion channel activity
 Lrrc8d ELISA Kit
 Lrrc8d Recombinant
 Lrrc8d Antibody
 Lrrc5 ELISA Kit
 Lrrc5 Recombinant
 Lrrc5 Antibody
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Volume-regulated anion channel subunit LRRC8E

 Volume-regulated anion channel subunit LRRC8E ELISA Kit
 Volume-regulated anion channel subunit LRRC8E Recombinant
 Volume-regulated anion channel subunit LRRC8E Antibody
Also known as Volume-regulated anion channel subunit LRRC8E (Leucine-rich repeat-containing protein 8E).
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also condu
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ct organic osmolytes like taurine. Channel activity requires lrrc8a plus at least one other family member (lrrc8b, lrrc8c, lrrc8d or lrrc8e); channel characteristics depend on the precise subunit composition.
 lrrc8e ELISA Kit
 lrrc8e Recombinant
 lrrc8e Antibody
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