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WASP homolog-associated protein

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Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Involved as a regulator of Golgi positioning and morphology. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration (By similarity). Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex.

Below are the list of possible WASP homolog-associated protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

WASP homolog-associated protein with actin, membranes and microtubules

 WASP homolog-associated protein with actin, membranes and microtubules ELISA Kit
 WASP homolog-associated protein with actin, membranes and microtubules Recombinant
 WASP homolog-associated protein with actin, membranes and microtubules Antibody
Also known as WASP homolog-associated protein with actin, membranes and microtubules (WAS protein homology region 2 domain-containing protein 1) (WH2 domain-containing protein 1).
WHAMM: Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex.

Cellular Component: cytoplasm; ER-Golgi intermediate compartment membrane; Golgi membrane

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Molecular Function: GTP-Rho binding; microtubule binding

Biological Process: actin filament organization; ER to Golgi vesicle-mediated transport; focal adhesion formation; lamellipodium biogenesis; positive regulation of actin nucleation
 Whamm ELISA Kit
 Whamm Recombinant
 Whamm Antibody
 Kiaa1971 ELISA Kit
 Kiaa1971 Recombinant
 Kiaa1971 Antibody
 Whdc1 ELISA Kit
 Whdc1 Recombinant
 Whdc1 Antibody
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