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Werner syndrome ATP-dependent helicase

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Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation.

Below are the list of possible Werner syndrome ATP-dependent helicase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Werner syndrome ATP-dependent helicase

 Werner syndrome ATP-dependent helicase ELISA Kit
 Werner syndrome ATP-dependent helicase Recombinant
 Werner syndrome ATP-dependent helicase Antibody
Also known as Werner syndrome ATP-dependent helicase (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (RecQ protein-like 2).
WRN: Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double- stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA mole
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cules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Monomer, and homooligomer. May exist as homodimer, homotrimer, homotetramer and/or homohexamer. Homotetramer, or homohexamer, when bound to DNA. Interacts via its N-terminal domain with WRNIP1. Interacts with EXO1, PCNA and SUPV3L1. Belongs to the helicase family. RecQ subfamily.

Protein type: Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus

Chromosomal Location of Human Ortholog: 8p12

Cellular Component: centrosome; cytoplasm; MutLalpha complex; nuclear chromosome, telomeric region; nucleolus; nucleoplasm

Molecular Function: 3'-5' DNA helicase activity; 3'-5' exonuclease activity; ATP-dependent 3'-5' DNA helicase activity; ATP-dependent DNA helicase activity; ATPase activity; bubble DNA binding; DNA binding; DNA helicase activity; exonuclease activity; four-way junction helicase activity; G-quadruplex DNA binding; helicase activity; magnesium ion binding; manganese ion binding; protein binding; protein complex binding; protein homodimerization activity; Y-form DNA binding

Biological Process: base-excision repair; cell aging; cellular response to starvation; DNA metabolic process; DNA replication; DNA synthesis during DNA repair; double-strand break repair; multicellular organismal aging; nucleolus to nucleoplasm transport; positive regulation of hydrolase activity; protein sumoylation; regulation of apoptosis; replication fork processing; response to DNA damage stimulus; response to oxidative stress; response to UV-C; strand displacement; telomere maintenance; telomere maintenance via recombination

Disease: Werner Syndrome
 WRN ELISA Kit
 WRN Recombinant
 WRN Antibody
 RECQ3 ELISA Kit
 RECQ3 Recombinant
 RECQ3 Antibody
 RECQL2 ELISA Kit
 RECQL2 Recombinant
 RECQL2 Antibody
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Werner syndrome ATP-dependent helicase homolog

 Werner syndrome ATP-dependent helicase homolog ELISA Kit
 Werner syndrome ATP-dependent helicase homolog Recombinant
 Werner syndrome ATP-dependent helicase homolog Antibody
Also known as Werner syndrome ATP-dependent helicase homolog (Exonuclease WRN).
WRN: Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double- stranded DNA. Binds preferentially to DNA substrates containing a
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lternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Monomer, and homooligomer. May exist as homodimer, homotrimer, homotetramer and/or homohexamer. Homotetramer, or homohexamer, when bound to DNA. Interacts via its N-terminal domain with WRNIP1. Interacts with EXO1, PCNA and SUPV3L1. Belongs to the helicase family. RecQ subfamily.

Protein type: Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus

Cellular Component: centrosome; cytoplasm; MutLalpha complex; neuron projection; nuclear chromosome, telomeric region; nucleolus; nucleoplasm; nucleus

Molecular Function: 3'-5' DNA helicase activity; 3'-5' exonuclease activity; ATP-dependent 3'-5' DNA helicase activity; ATP-dependent DNA helicase activity; ATPase activity; bubble DNA binding; chromatin binding; DNA binding; DNA helicase activity; exonuclease activity; four-way junction helicase activity; G-quadruplex DNA binding; helicase activity; magnesium ion binding; manganese ion binding; protein binding; protein complex binding; protein homodimerization activity; Y-form DNA binding

Biological Process: base-excision repair; cell aging; cellular response to starvation; DNA duplex unwinding; DNA metabolic process; DNA replication; DNA synthesis during DNA repair; double-strand break repair; multicellular organismal aging; nucleolus to nucleoplasm transport; positive regulation of hydrolase activity; regulation of apoptosis; regulation of growth rate; replication fork processing; replicative cell aging; response to DNA damage stimulus; response to oxidative stress; response to UV-C; telomere maintenance; telomere maintenance via recombination
 Wrn ELISA Kit
 Wrn Recombinant
 Wrn Antibody
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