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Wilms tumor protein 1-interacting protein

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Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture. In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype.

Below are the list of possible Wilms tumor protein 1-interacting protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Wilms tumor protein 1-interacting protein

 Wilms tumor protein 1-interacting protein ELISA Kit
 Wilms tumor protein 1-interacting protein Recombinant
 Wilms tumor protein 1-interacting protein Antibody
Also known as Wilms tumor protein 1-interacting protein (WT1-interacting protein).
WTIP: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Posi
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tively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. In case of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator that represses WT1- dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Belongs to the zyxin/ajuba family.

Protein type: Adaptor/scaffold; Cell development/differentiation; Transcription, coactivator/corepressor

Cellular Component: adherens junction; intercellular junction; nucleus; transcription factor complex

Molecular Function: protein binding; transcription corepressor activity

Biological Process: cytoskeleton organization and biogenesis; miRNA-mediated gene silencing; regulation of cell morphogenesis; regulation of transcription, DNA-dependent; response to hypoxia
 Wtip ELISA Kit
 Wtip Recombinant
 Wtip Antibody
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Wilms tumor protein 1-interacting protein homolog

 Wilms tumor protein 1-interacting protein homolog ELISA Kit
 Wilms tumor protein 1-interacting protein homolog Recombinant
 Wilms tumor protein 1-interacting protein homolog Antibody
Also known as Wilms tumor protein 1-interacting protein homolog (WT1-interacting protein homolog).
May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. In case of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator. Plays a role in the regulation of cell morphology and cytoskeletal organization (). Acts as a tr
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anscriptional corepressor for snai1 and snai2/slug and plays a role in regulating neural crest development ().
 wtip ELISA Kit
 wtip Recombinant
 wtip Antibody
 si:ch211-79l17.3 ELISA Kit
 si:ch211-79l17.3 Recombinant
 si:ch211-79l17.3 Antibody
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