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X-box-binding protein

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Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland. Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes. Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention.

Below are the list of possible X-box-binding protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

X-box-binding protein 1

 X-box-binding protein 1 ELISA Kit
 X-box-binding protein 1 Recombinant
 X-box-binding protein 1 Antibody
Also known as X-box-binding protein 1 (Hepatocarcinogenesis-related transcription factor) (HTF).
XBP1: a transcription factor essential for hepatocyte growth, the differentiation of plasma cells, immunoglobulin secretion, and the unfolded protein response (UPR). XBP1 mRNA is spliced by IRE1 during the UPR to generate a new C-terminus, converting it into a potent unfolded-protein response transc
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riptional activator and triggering growth arrest and apoptosis. Only the spliced form of XBP1 can activate the UPR efficiently. Activates UPR target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I. Up-regulated by ATF6 via direct binding to the ERSE in response to endoplasmic reticulum stress. Genetic variations in XBP1 could be associated with susceptibility to major affective disorder type 7 (MAFD7). Major affective disorders represent a class of mental disorders characterized by a disturbance in mood as their predominant feature. Two human isoforms are produced by alternative splicing. Isoform 1 is also known as XBP-1U. Isoform 2, also known as XBP-1S, is produced by IRE1 in response to endoplasmic reticulum stress. IRE1 cleaves a 26-bp fragment causing a frameshift of the mRNA transcript.

Protein type: DNA-binding; Transcription factor

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; integral to endoplasmic reticulum membrane; nucleus

Molecular Function: chromatin DNA binding; DNA binding; protease binding; protein heterodimerization activity; protein kinase binding; sequence-specific DNA binding; transcription factor activity; ubiquitin protein ligase binding

Biological Process: angiogenesis; cell growth; cellular response to glucose starvation; cholesterol homeostasis; endothelial cell proliferation; epithelial cell maturation; exocrine pancreas development; fatty acid homeostasis; glucose homeostasis; liver development; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; phosphoinositide 3-kinase cascade; positive regulation of autophagy; positive regulation of B cell differentiation; positive regulation of fat cell differentiation; positive regulation of histone methylation; positive regulation of immunoglobulin production; positive regulation of MHC class II biosynthetic process; positive regulation of protein amino acid phosphorylation; positive regulation of T cell differentiation; positive regulation of TOR signaling pathway; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription of target genes involved in unfolded protein response; protein destabilization; regulation of autophagy; regulation of protein stability; regulation of transcription, DNA-dependent; response to drug; response to electrical stimulus; serotonin secretion, neurotransmission; sterol homeostasis; transcription from RNA polymerase II promoter; ubiquitin-dependent protein catabolic process; unfolded protein response; vascular endothelial growth factor receptor signaling pathway
 Xbp1 ELISA Kit
 Xbp1 Recombinant
 Xbp1 Antibody
 Htf ELISA Kit
 Htf Recombinant
 Htf Antibody
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