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YTH domain-containing protein

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Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10. Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing. May also regulate alternative splice site selection.

Below are the list of possible YTH domain-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

YTH domain-containing protein 1

 YTH domain-containing protein 1 ELISA Kit
 YTH domain-containing protein 1 Recombinant
 YTH domain-containing protein 1 Antibody
YT521: May be part of a signal transduction pathway that influences splice site selection. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA splicing; RNA-binding

Cellular Component: nuclear body; nuclear speck; nucleoplasm; nucleus

Molecular Function: RNA binding

Biological Process: mRNA splice site selection; nuclear mRNA splicing
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, via spliceosome; regulation of nuclear mRNA splicing, via spliceosome
 Ythdc1 ELISA Kit
 Ythdc1 Recombinant
 Ythdc1 Antibody
 Kiaa1966 ELISA Kit
 Kiaa1966 Recombinant
 Kiaa1966 Antibody
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YTH domain-containing protein 2

 YTH domain-containing protein 2 ELISA Kit
 YTH domain-containing protein 2 Recombinant
 YTH domain-containing protein 2 Antibody
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability.
 YTHDC2 ELISA Kit
 YTHDC2 Recombinant
 YTHDC2 Antibody
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YTH domain-containing protein mmi1

 YTH domain-containing protein mmi1 ELISA Kit
 YTH domain-containing protein mmi1 Recombinant
 YTH domain-containing protein mmi1 Antibody
Also known as YTH domain-containing protein mmi1 (Meiotic mRNA interception protein 1).
RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs (). Required for elemination of certain meiosis-specific mRNAs in an early event following transcription. May bind to the cis-acting region (DSR)
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of the mRNA, activating the nuclear exosome which may lead to the degradation of the transcript from the 3' region (PubMed:16823445).
 mmi1 ELISA Kit
 mmi1 Recombinant
 mmi1 Antibody
 SPCC736.12c ELISA Kit
 SPCC736.12c Recombinant
 SPCC736.12c Antibody
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