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Zinc finger CCCH-type antiviral protein

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Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1) and moloney and murine leukemia virus (MoMLV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).

Below are the list of possible Zinc finger CCCH-type antiviral protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Zinc finger CCCH-type antiviral protein 1

 Zinc finger CCCH-type antiviral protein 1 ELISA Kit
 Zinc finger CCCH-type antiviral protein 1 Recombinant
 Zinc finger CCCH-type antiviral protein 1 Antibody
Also known as Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13).
ZAP: Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)- specific ribonuclease PARN to re
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move the poly(A) tail, and the 3'- 5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). 5 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Transferase

Cellular Component: cell-cell adherens junction; cytoplasm; Golgi apparatus; late endosome; lysosome; nucleus

Molecular Function: DEAD/H-box RNA helicase binding

Biological Process: negative regulation of viral genome replication; positive regulation of ATPase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon type I production; regulation of defense response to virus by host; response to virus
 Zc3hav1 ELISA Kit
 Zc3hav1 Recombinant
 Zc3hav1 Antibody
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Zinc finger CCCH-type antiviral protein 1-like

 Zinc finger CCCH-type antiviral protein 1-like ELISA Kit
 Zinc finger CCCH-type antiviral protein 1-like Recombinant
 Zinc finger CCCH-type antiviral protein 1-like Antibody
ZC3HAV1L: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function
 Zc3hav1l ELISA Kit
 Zc3hav1l Recombinant
 Zc3hav1l Antibody
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