Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL or DOK1. Required for adhesion-dependent phosphorylation of ARHGAP35 which promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
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Arg: a cytoplasmic tyrosine kinase of the Abl family. Expressed at the highest levels in mature B cells. Promotes catalase degradation in the oxidative stress response. Localizes to dynamic actin structures and may regulate cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Abl family; EC 220.127.116.11; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Cellular Component: actin cytoskeleton; cytoplasmic vesicle; dendritic spine; extrinsic to internal side of plasma membrane; lamellipodium; phagocytic cup
Molecular Function: magnesium ion binding; manganese ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity
Biological Process: actin cytoskeleton organization and biogenesis; actin filament bundle formation; actin filament organization; alpha-beta T cell differentiation; Bergmann glial cell differentiation; cerebellum morphogenesis; dendrite morphogenesis; elevation of cytosolic calcium ion concentration; epidermal growth factor receptor signaling pathway; innate immune response; learning; negative regulation of cell-cell adhesion; negative regulation of Rho protein signal transduction; neuromuscular process controlling balance; neuron remodeling; peptidyl-tyrosine phosphorylation; phagocytosis; platelet-derived growth factor receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of oxidoreductase activity; positive regulation of protein binding; protein amino acid phosphorylation; regulation of cell proliferation; substrate-bound cell migration, cell extension; visual learning
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