Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
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ZFYVE19: A chromosomal aberration involving ZFYVE19 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with MLL/HRX. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: centrosome; cleavage furrow; midbody
Molecular Function: phosphatidylinositol 3-phosphate binding; protein binding
Biological Process: abscission; negative regulation of cytokinesis
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