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Acetyl-CoA acetyltransferase

CATALYTIC ACTIVITY: 2 acetyl-CoA = CoA + acetoacetyl-CoA. .

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Acetyl-CoA acetyltransferase A

Also known as Acetyl-CoA acetyltransferase A, mitochondrial (Acetoacetyl-CoA thiolase A).
Plays a major role in ketone body metabolism.

Acetyl-CoA acetyltransferase B

Also known as Acetyl-CoA acetyltransferase B, mitochondrial (Acetoacetyl-CoA thiolase B).
Plays a major role in ketone body metabolism.

Acetyl-CoA acetyltransferase homolog

Also known as Acetyl-CoA acetyltransferase homolog, mitochondrial (3-ketoacyl-CoA thiolase).
Plays a role in ketone body metabolism (). Has an effect on lysosome related organelles (LRO) function, in a pathway with serotonin (PubMed:24204312). Acts downstream of sir-2.1 to regulate aging and stress resistance (PubMed:20956318).

Acetyl-CoA acetyltransferase, cytosolic

Also known as Acetyl-CoA acetyltransferase, cytosolic (Acetyl-CoA transferase-like protein) (Cytosolic acetoacetyl-CoA thiolase).
ACAT2: The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. [provided by RefSeq, Jul 2008]

Protein type: Acetyltransferase; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 2.3.1.9; Lipid Metabolism - fatty acid; Lipid Metabolism - synthesis and degradation of ketone bodies; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: cytoplasm; mitochondrion; nucleolus; nucleus

Molecular Function: acetyl-CoA C-acetyltransferase activity; protein binding

Biological Process: fatty acid beta-oxidation; lipid metabolic process

Disease: Acetyl-coa Acetyltransferase-2 Deficiency

Acetyl-CoA acetyltransferase, cytosolic 1

Also known as Acetyl-CoA acetyltransferase, cytosolic 1 (Cytosolic acetoacetyl-CoA thiolase 1) (Thiolase 1) (Protein EMBRYO DEFECTIVE 1276).
Encodes an acetoacetyl-CoA thiolase that generates the bulk of the acetoacetyl-CoA precursor needed for the cytosolic localized, mevalonate-derived isoprenoids biosynthetic pathway. Loss-of-function mutants are embryo lethal.

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