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Acetyl-coenzyme A synthetase

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

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Acetyl-coenzyme A synthetase

Also known as Acetyl-coenzyme A synthetase (AcCoA synthetase) (Acs) (Acetate--CoA ligase) (Acyl-activating enzyme).
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

Acetyl-coenzyme A synthetase 1

Also known as Acetyl-coenzyme A synthetase 1 (AcCoA synthetase 1) (Acs 1) (Acetate--CoA ligase 1) (Acyl-activating enzyme 1).
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

Acetyl-coenzyme A synthetase 2

Also known as Acetyl-coenzyme A synthetase 2 (AcCoA synthetase 2) (Acs 2) (Acetate--CoA ligase 2) (Acyl-activating enzyme 2).
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

Acetyl-coenzyme A synthetase 2-like

Also known as Acetyl-coenzyme A synthetase 2-like, mitochondrial (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (AceCS2) (Acyl-CoA synthetase short-chain family member 1).
ACSS1: Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions. Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2). Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.2.1.1; Ligase; Mitochondrial

Chromosomal Location of Human Ortholog: 20p11.21

Cellular Component: mitochondrial matrix

Molecular Function: acetate-CoA ligase activity; protein binding

Biological Process: acetyl-CoA biosynthetic process; ethanol oxidation

Acetyl-coenzyme A synthetase, cytoplasmic

Also known as Acetyl-coenzyme A synthetase, cytoplasmic (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme).
ACSS2: Activates acetate so that it can be used for lipid synthesis or for energy generation. Monomer. Belongs to the ATP-dependent AMP-binding enzyme family.

Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.2.1.1; Ligase

Cellular Component: cytoplasm; intracellular membrane-bound organelle; nucleoplasm

Molecular Function: acetate-CoA ligase activity

Biological Process: acetate biosynthetic process; acetyl-CoA biosynthetic process; lipid biosynthetic process; propionate biosynthetic process
Proteins Root Name Listing
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