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Acid-sensing ion channel

Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions.

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Acid-sensing ion channel 1

Also known as Acid-sensing ion channel 1 (ASIC1) (Acid-sensing ion channel 1.1) (Amiloride-sensitive cation channel 2-A, neuronal) (ZASIC1.1).
Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions.

Acid-sensing ion channel 2

Also known as Acid-sensing ion channel 2 (ASIC2) (Amiloride-sensitive brain sodium channel) (Amiloride-sensitive brain sodium channel 2) (Amiloride-sensitive cation channel 1, neuronal) (Amiloride-sensitive cation channel neuronal 1) (Brain sodium channel 1) (BNC1) (BNaC1) (Mammalian degenerin homolog) (MDEG).
ASIC2: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Cellular Component: cell soma; dendritic spine; integral to membrane; integral to plasma membrane; neuron projection; synapse

Molecular Function: amiloride-sensitive sodium channel activity; cation channel activity; ion channel activity; ion gated channel activity; voltage-gated sodium channel activity

Biological Process: cation transport; detection of mechanical stimulus involved in sensory perception; negative regulation of apoptosis; phototransduction; positive regulation of synaptogenesis; regulation of blood coagulation; regulation of gene expression; regulation of membrane potential; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; regulation of vasoconstriction; response to acidity; response to mechanical stimulus; sensory perception of sound; sensory perception of sour taste; sodium ion transport

Acid-sensing ion channel 3

Also known as Acid-sensing ion channel 3 (ASIC3) (Amiloride-sensitive cation channel 3) (Dorsal root ASIC) (DRASIC).
ASIC3: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Cellular Component: integral to plasma membrane

Molecular Function: amiloride-sensitive sodium channel activity; cation channel activity; enterobactin transporter activity; PDZ domain binding; protein binding

Biological Process: cation transport; detection of chemical stimulus involved in sensory perception; detection of chemical stimulus involved in sensory perception of pain; detection of mechanical stimulus involved in sensory perception; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception; detection of temperature stimulus involved in sensory perception of pain; response to acidity; response to heat; response to mechanical stimulus; sensory perception of sour taste; sodium ion transport

Acid-sensing ion channel 4

Also known as Acid-sensing ion channel 4 (ASIC4) (Acid-sensing ion channel 4.1) (Amiloride-sensitive cation channel 4-A) (ZASIC4.1).
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride.

Acid-sensing ion channel 5

Also known as Acid-sensing ion channel 5 (ASIC5) (Amiloride-sensitive cation channel 5) (Brain-liver-intestine amiloride-sensitive Na(+) channel) (BLINaC).
ASIC5: Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily.

Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Cellular Component: membrane

Molecular Function: amiloride-sensitive sodium channel activity; hydrogen ion channel activity; sodium channel activity

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