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Actin-binding LIM protein

May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.

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Actin-binding LIM protein 1

Also known as Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1).
abLIM: a cytoskeletal LIM protein consisting of a C-terminal cytoskeletal domain fused to an N-terminal domain of four double zinc finger motifs. The C-terminal domain is 50% identical to dematin, an actin-bundling protein of the erythroid cytoskeleton. Undergoes extensive phosphorylation in light-adapted retinas in vivo and its developmental expression in the retina coincides with the elaboration of photoreceptor inner and outer segments. Three distinct splice variant isoforms have been described: ABLIM-l, ABLIM-m, ABLIM-s.

Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis

Cellular Component: actin cytoskeleton; lamellipodium; postsynaptic density; stress fiber

Molecular Function: actin binding

Biological Process: axon guidance; lamellipodium biogenesis; positive regulation of transcription from RNA polymerase II promoter

Actin-binding LIM protein 2

Also known as Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2).
ABLIM2: May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Cellular Component: actin cytoskeleton; myofibril

Biological Process: positive regulation of transcription from RNA polymerase II promoter

Actin-binding LIM protein 3

Also known as Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3).
ABLIM3: May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis

Cellular Component: lamellipodium; stress fiber

Biological Process: lamellipodium biogenesis; positive regulation of transcription from RNA polymerase II promoter

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