May be involved in the spatial organization of cell surface growth. An overproduction of ABP1 causes the assembly of the cortical actin skeleton at inappropriate sites on the cell surface, resulting in delocalized surface growth (By similarity).
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IPP: May play a role in organizing the actin cytoskeleton. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 1p34-p32
Cellular Component: actin cytoskeleton
Molecular Function: ubiquitin-protein ligase activity
Directly binds F-actin, which results in thickened and distorted F-actin fibers, and affects cellular F-actin localization. Thus, may be a host effector whose function is to disrupt host actin cytoskeletal structure, which may enhance invasion.
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