Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.
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ABRA: Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.
Protein type: Actin-binding; Contractile; Transcription, coactivator/corepressor
Cellular Component: actin cytoskeleton; myofibril; plasma membrane; sarcomere
Molecular Function: actin binding
Biological Process: positive regulation of Rho protein signal transduction; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein import into nucleus, translocation
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