• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Activating molecule in BECN1-regulated autophagy protein

Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity).

Below are the list of possible Activating molecule in BECN1-regulated autophagy protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Activating molecule in BECN1-regulated autophagy protein 1

AMBRA1: a WD40 protein that regulates autophagy and development of the nervous system. A highly conserved vertebrate protein whose expression is mostly confined to the neuroepithelium during early neurogenesis. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. Interacts with ATG6. Forms a complex with ATG6 and PIK3C3. Its functional inactivation in mouse is lethal in utero (starting from embryonic day 14.5), leading to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, and excessive apoptosis. Hyperproliferation followed by a wave of caspase-dependent cell death was the earliest detectable abnormality in the developing neuroepithelium. Five isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy; Vesicle

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: axoneme; cytoplasm; cytosol; mitochondrion; perinuclear region of cytoplasm

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: macroautophagy; positive regulation of phosphoinositide 3-kinase activity
Proteins Root Name Listing
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000