Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation .
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TRIP4: thyroid receptor interacting protein 4 is a transcription coactivator of nuclear receptors including thyroid hormone receptor. Functions in conjunction with CBP-p300 and SRC-1. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. Plays a role in androgen receptor transactivation and in testicular function
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 15q22.31
Cellular Component: cytoplasm; neuromuscular junction; nucleoplasm; nucleus
Molecular Function: estrogen receptor binding; histone acetyltransferase binding; ligand-dependent nuclear receptor binding; protease binding; protein binding; transcription coactivator activity
Biological Process: estrogen receptor signaling pathway; positive regulation of transcription, DNA-dependent; regulation of myoblast differentiation; regulation of transcription, DNA-dependent
Disease: Muscular Dystrophy, Congenital, Davignon-chauveau Type; Spinal Muscular Atrophy With Congenital Bone Fractures 1
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