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Activating signal cointegrator 1 complex

Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.

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Activating signal cointegrator 1 complex subunit 1

Also known as Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50).
ASCC1: Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. Defects in ASCC1 may be a cause of Barrett esophagus (BE). A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Genetic variants in ASCC1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 10pter-q25.3

Cellular Component: neuromuscular junction; nucleoplasm; nucleus; transcription factor complex

Molecular Function: protein binding

Biological Process: DNA dealkylation; regulation of transcription, DNA-dependent

Disease: Barrett Esophagus; Spinal Muscular Atrophy With Congenital Bone Fractures 2

Activating signal cointegrator 1 complex subunit 2

Also known as Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100).
ASCC2: Enhances NF-kappa-B, SRF and AP1 transactivation. Belongs to the ASCC2 family. 2 isoforms of the human protein are produced by alternative splicing.

Cellular Component: nucleus

Biological Process: regulation of transcription, DNA-dependent

Activating signal cointegrator 1 complex subunit 3

ASCC3: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation. Belongs to the helicase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.12; Helicase; Transcription, coactivator/corepressor

Cellular Component: cytoplasm; Golgi apparatus; intracellular; membrane; nucleus

Molecular Function: ATP-dependent 3'-5' DNA helicase activity

Biological Process: cell proliferation; DNA dealkylation; DNA duplex unwinding
Proteins Root Name Listing
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