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Acyl-coenzyme A synthetase

Functions as GTP-dependent lipoate-activating enzyme that generates the substrate for lipoyltransferase (By similarity). Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro).

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Acyl-coenzyme A synthetase ACSM1

Also known as Acyl-coenzyme A synthetase ACSM1, mitochondrial (Acyl-CoA synthetase medium-chain family member 1) (Butyrate--CoA ligase 1) (Butyryl-coenzyme A synthetase 1) (Lipoate-activating enzyme) (Middle-chain acyl-CoA synthetase 1).
ACSM1: Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). Functions as GTP-dependent lipoate- activating enzyme that generates the substrate for lipoyltransferase. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - butanoate; EC 6.2.1.2; Ligase; Mitochondrial

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: acyl-CoA ligase activity; butyrate-CoA ligase activity; fatty-acid ligase activity; fatty-acyl-CoA synthase activity

Biological Process: acyl-CoA metabolic process; fatty acid biosynthetic process

Acyl-coenzyme A synthetase ACSM2

Also known as Acyl-coenzyme A synthetase ACSM2, mitochondrial (Acyl-CoA synthetase medium-chain family member 2) (Butyrate--CoA ligase 2) (Butyryl-coenzyme A synthetase 2) (Kidney-specific protein KS) (Middle-chain acyl-CoA synthetase 2).
ACSM2A: an acyl-CoA synthetase. Acyl-CoA synthetases catalyze the first reaction of amino acid conjugation in fatty acid metabolism and of many xenobiotic carboxylic acids. A liver enzyme implicated in the metabolism of xenobiotic carboxylic acids such as pesticides, arylpropionate anti-inflammatory drugs and hypolipidaemic clofibrate and its congeners.

Protein type: Carbohydrate Metabolism - butanoate; EC 6.2.1.2; Ligase; Mitochondrial

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: acyl-CoA ligase activity; butyrate-CoA ligase activity; fatty-acid ligase activity; fatty-acyl-CoA synthase activity

Biological Process: acyl-CoA metabolic process; fatty acid biosynthetic process

Acyl-coenzyme A synthetase ACSM2A

Also known as Acyl-coenzyme A synthetase ACSM2A, mitochondrial (Acyl-CoA synthetase medium-chain family member 2A) (Butyrate--CoA ligase 2A) (Butyryl-coenzyme A synthetase 2A) (Middle-chain acyl-CoA synthetase 2A).
ACSM2A: an acyl-CoA synthetase. Acyl-CoA synthetases catalyze the first reaction of amino acid conjugation in fatty acid metabolism and of many xenobiotic carboxylic acids. A liver enzyme implicated in the metabolism of xenobiotic carboxylic acids such as pesticides, arylpropionate anti-inflammatory drugs and hypolipidaemic clofibrate and its congeners.

Protein type: Carbohydrate Metabolism - butanoate; EC 6.2.1.2; Ligase; Mitochondrial

Chromosomal Location of Human Ortholog: 16p12.3

Cellular Component: mitochondrial matrix

Molecular Function: acyl-CoA ligase activity; butyrate-CoA ligase activity; fatty-acid ligase activity; fatty-acyl-CoA synthase activity

Biological Process: fatty acid biosynthetic process

Acyl-coenzyme A synthetase ACSM2B

Also known as Acyl-coenzyme A synthetase ACSM2B, mitochondrial (Acyl-CoA synthetase medium-chain family member 2B) (Butyrate--CoA ligase 2B) (Butyryl-coenzyme A synthetase 2B) (Middle-chain acyl-CoA synthetase 2B) (Xenobiotic/medium-chain fatty acid-CoA li.
Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C4 to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro).

Acyl-coenzyme A synthetase ACSM3

Also known as Acyl-coenzyme A synthetase ACSM3, mitochondrial (Acyl-CoA synthetase medium-chain family member 3) (Butyrate--CoA ligase 3) (Butyryl-coenzyme A synthetase 3) (Middle-chain acyl-CoA synthetase 3) (Protein SA homolog).
ACSM3: Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - butanoate; EC 6.2.1.2; Ligase; Mitochondrial

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: acyl-CoA ligase activity; fatty-acid ligase activity; fatty-acyl-CoA synthase activity

Biological Process: acyl-CoA metabolic process; fatty acid biosynthetic process

Acyl-coenzyme A synthetase ACSM4

Also known as Acyl-coenzyme A synthetase ACSM4, mitochondrial (Acyl-CoA synthetase medium-chain family member 4).
ACSM4: Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). Belongs to the ATP-dependent AMP-binding enzyme family.

Protein type: Carbohydrate Metabolism - butanoate; EC 6.2.1.2; Ligase; Mitochondrial

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: mitochondrial matrix

Molecular Function: acyl-CoA ligase activity; fatty-acid ligase activity; fatty-acyl-CoA synthase activity

Biological Process: acyl-CoA metabolic process; fatty acid biosynthetic process

Acyl-coenzyme A synthetase ACSM5

Also known as Acyl-coenzyme A synthetase ACSM5, mitochondrial.
ACSM5: Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - butanoate; EC 6.2.1.2; Ligase; Mitochondrial

Cellular Component: mitochondrial matrix

Molecular Function: acyl-CoA ligase activity; fatty-acid ligase activity; fatty-acyl-CoA synthase activity

Biological Process: acyl-CoA metabolic process; fatty acid biosynthetic process

Acyl-coenzyme A synthetase ACSM6

Also known as Acyl-coenzyme A synthetase ACSM6, mitochondrial (Acyl-CoA synthetase medium-chain family member 6).
ACSM6: Belongs to the ATP-dependent AMP-binding enzyme family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.2.1.2; Ligase

Chromosomal Location of Human Ortholog: 10q23.33

Cellular Component: mitochondrial matrix

Molecular Function: acyl-CoA ligase activity; fatty-acid ligase activity; fatty-acyl-CoA synthase activity

Biological Process: acyl-CoA metabolic process; fatty acid biosynthetic process; regulation of protein stability

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