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Acyl-coenzyme A thioesterase

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity).

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Acyl-coenzyme A thioesterase 1

Also known as Acyl-coenzyme A thioesterase 1 (Acyl-CoA thioesterase 1) (CTE-I) (CTE-Ib) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase).
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 ().

Acyl-coenzyme A thioesterase 10

Also known as Acyl-coenzyme A thioesterase 10, mitochondrial (Acyl-CoA thioesterase 10) (Mitochondrial 48 kDa acyl-CoA thioester hydrolase 2) (Mt-ACT48.2).
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs.

Acyl-coenzyme A thioesterase 11

Also known as Acyl-coenzyme A thioesterase 11 (Acyl-CoA thioesterase 11) (Acyl-CoA thioester hydrolase 11) (Adipose-associated thioesterase) (Brown fat-inducible thioesterase) (BFIT).
ACOT11: Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.2.-; Hydrolase

Cellular Component: cytosol

Molecular Function: acyl-CoA hydrolase activity

Biological Process: acyl-CoA metabolic process; fatty acid metabolic process; response to cold; response to temperature stimulus

Acyl-coenzyme A thioesterase 12

Also known as Acyl-coenzyme A thioesterase 12 (Acyl-CoA thioesterase 12) (Acyl-CoA thioester hydrolase 12) (Cytoplasmic acetyl-CoA hydrolase 1) (CACH-1) (hCACH-1) (START domain-containing protein 15) (StARD15).
ACOT12: Hydrolyzes acetyl-CoA to acetate and CoA.

Protein type: Carbohydrate Metabolism - pyruvate; EC 3.1.2.1; Hydrolase

Chromosomal Location of Human Ortholog: 5q14.1

Cellular Component: cytosol

Molecular Function: acetyl-CoA hydrolase activity; acyl-CoA hydrolase activity

Biological Process: acetyl-CoA metabolic process; acyl-CoA metabolic process; fatty acid metabolic process

Acyl-coenzyme A thioesterase 13

Also known as Acyl-coenzyme A thioesterase 13 (Acyl-CoA thioesterase 13) (Thioesterase superfamily member 2).
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA (in vitro) (). May play a role in controlling adaptive thermogenesis ().

Acyl-coenzyme A thioesterase 2

Also known as Acyl-coenzyme A thioesterase 2, mitochondrial (Acyl-CoA thioesterase 2) (Acyl coenzyme A thioester hydrolase) (MTE-I) (Very-long-chain acyl-CoA thioesterase).
ACOT2: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs. Belongs to the C/M/P thioester hydrolase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.2.2; Hydrolase; Lipid Metabolism - unsaturated fatty acid biosynthesis; Mitochondrial

Cellular Component: mitochondrion

Molecular Function: acyl-CoA hydrolase activity; palmitoyl-CoA hydrolase activity; receptor binding

Biological Process: acyl-CoA metabolic process; long-chain fatty acid metabolic process; response to hypoxia; very-long-chain fatty acid catabolic process; very-long-chain fatty acid metabolic process

Acyl-coenzyme A thioesterase 3

Also known as Acyl-coenzyme A thioesterase 3 (Acyl-CoA thioesterase 3) (PTE-Ia) (Peroxisomal acyl-coenzyme A thioester hydrolase 2a) (Peroxisomal long-chain acyl-CoA thioesterase 2).
ACOT3: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Mainly active on long-chain acyl-CoAs. May have a function in termination of beta-oxidation of fatty acids. Belongs to the C/M/P thioester hydrolase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.2.2; Hydrolase

Cellular Component: cytosol; peroxisome

Molecular Function: acyl-CoA hydrolase activity

Biological Process: acyl-CoA metabolic process; long-chain fatty acid metabolic process; saturated monocarboxylic acid metabolic process; unsaturated monocarboxylic acid metabolic process; very-long-chain fatty acid metabolic process

Acyl-coenzyme A thioesterase 4

Also known as Acyl-coenzyme A thioesterase 4 (Acyl-CoA thioesterase 4) (PTE-2b) (Peroxisomal acyl coenzyme A thioester hydrolase Ib) (Peroxisomal long-chain acyl-CoA thioesterase Ib) (PTE-Ib).
ACOT4: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs. Belongs to the C/M/P thioester hydrolase family.

Protein type: EC 3.1.2.2; Hydrolase; Lipid Metabolism - unsaturated fatty acid biosynthesis

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: peroxisomal matrix; peroxisome

Molecular Function: acyl-CoA hydrolase activity; receptor binding; succinyl-CoA hydrolase activity

Biological Process: acyl-CoA metabolic process; butyrate metabolic process; dicarboxylic acid catabolic process; dicarboxylic acid metabolic process; long-chain fatty acid metabolic process; saturated monocarboxylic acid metabolic process; short-chain fatty acid metabolic process; succinyl-CoA metabolic process; unsaturated monocarboxylic acid metabolic process; very-long-chain fatty acid metabolic process

Acyl-coenzyme A thioesterase 5

Also known as Acyl-coenzyme A thioesterase 5 (Acyl-CoA thioesterase 5) (Peroxisomal acyl-coenzyme A thioester hydrolase Ic) (Peroxisomal acyl-CoA thioesterase Ic).
ACOT5: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Seems to be involved in intraperoxisomal regulation of acyl-CoA levels, but not CoASH levels. Mainly active on medium-chain acyl- CoAs. May have a function in termination of beta-oxidation of fatty acids. Belongs to the C/M/P thioester hydrolase family.

Protein type: EC 3.1.2.2; Hydrolase

Cellular Component: cytosol; peroxisome

Molecular Function: acyl-CoA hydrolase activity

Biological Process: acyl-CoA metabolic process; long-chain fatty acid metabolic process; saturated monocarboxylic acid metabolic process; unsaturated monocarboxylic acid metabolic process; very-long-chain fatty acid metabolic process

Acyl-coenzyme A thioesterase 6

Also known as Acyl-coenzyme A thioesterase 6 (Acyl-CoA thioesterase 6).
ACOT6: Belongs to the C/M/P thioester hydrolase family.

Protein type: EC 3.1.2.-; Hydrolase

Cellular Component: peroxisome

Acyl-coenzyme A thioesterase 8

Also known as Acyl-coenzyme A thioesterase 8 (Acyl-CoA thioesterase 8) (Choloyl-coenzyme A thioesterase) (HIV-Nef-associated acyl-CoA thioesterase) (PTE-2) (Peroxisomal acyl-coenzyme A thioester hydrolase 1) (PTE-1) (Peroxisomal long-chain acyl-CoA thioes.
ACOT8: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N- acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs. May be involved in the metabolic regulation of peroxisome proliferation. Belongs to the C/M/P thioester hydrolase family.

Protein type: EC 3.1.2.27; Hydrolase

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: peroxisomal matrix

Molecular Function: acetyl-CoA hydrolase activity; acyl-CoA hydrolase activity; CoA hydrolase activity; palmitoyl-CoA hydrolase activity; protein binding; receptor binding

Biological Process: acyl-CoA metabolic process; bile acid biosynthetic process; dicarboxylic acid catabolic process; fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid catabolic process; negative regulation of CD4 biosynthetic process; peroxisome fission

Acyl-coenzyme A thioesterase 9

Also known as Acyl-coenzyme A thioesterase 9, mitochondrial (Acyl-CoA thioesterase 9) (Acyl coenzyme A thioester hydrolase 2) (MTE-2) (Acyl-CoA thioester hydrolase 9) (Mitochondrial 48 kDa acyl-CoA thioester hydrolase 1) (Mt-ACT48.1) (Protein U8) (p48).
ACOT9: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs. Belongs to the acyl coenzyme A hydrolase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.2.-; Hydrolase

Cellular Component: mitochondrion

Molecular Function: acetyl-CoA hydrolase activity; acyl-CoA hydrolase activity; protein binding

Biological Process: acyl-CoA metabolic process

Acyl-coenzyme A thioesterase PaaI

Also known as Acyl-coenzyme A thioesterase PaaI (Phenylacetic acid degradation protein PaaI).
Has a hot-dog fold. [More information is available at EcoGene: EG13743]. PaaI belongs to the hotdog-fold superfamily and the acyl-CoA thioesterase subfamily of enzymes. [More information is available at EcoCyc: G6717].

Acyl-coenzyme A thioesterase THEM4

Also known as Acyl-coenzyme A thioesterase THEM4 (Acyl-CoA thioesterase THEM4) (Carboxyl-terminal modulator protein) (Thioesterase superfamily member 4).
CTMP: According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. Interacts with AKT1. Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation.

Protein type: EC 3.1.2.2; Mitochondrial

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytosol; mitochondrial matrix; mitochondrion; plasma membrane

Molecular Function: acyl-CoA hydrolase activity; palmitoyl-CoA hydrolase activity

Biological Process: fatty acid metabolic process; protein kinase B signaling cascade

Acyl-coenzyme A thioesterase THEM5

Also known as Acyl-coenzyme A thioesterase THEM5 (Acyl-CoA thioesterase THEM5) (Acyl-coenzyme A thioesterase 15) (Thioesterase superfamily member 5).
THEM5: Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleyl-CoA and other unsaturated long-chain fatty acid-CoA esters. Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin. Required for normal mitochondrial function. Belongs to the THEM4/THEM5 thioesterase family. Homodimer

Protein type: EC 3.1.2.2

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: mitochondrial matrix

Molecular Function: acyl-CoA hydrolase activity; palmitoyl-CoA hydrolase activity; protein binding

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