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Acyltransferase

Acyltransferase that catalyzes the formation of lovastatin from monacolin J and LovF-bound 2-methylbutyrate. Can also convert monacolin J to simvastatin using alpha-dimethylbutyryl-S-methyl-3-mercaptopropionate (DMB-S-MMP) as the thioester acyl donor. Has broad substrate specificity and can utilize a variety of acyl donors and monacolin analogs (in vitro). Has much higher activity with LovF-bound 2-methylbutyrate than with free diketide substrates. Can also catalyze the reverse reaction and function as hydrolase (in vitro).

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Acyltransferase LovD

Also known as Acyltransferase LovD (Lovastatin hydrolase) (Simvastatin synthase LovD) (SV synthase).
Acyltransferase that catalyzes the formation of lovastatin from monacolin J and LovF-bound 2-methylbutyrate. Can also convert monacolin J to simvastatin using alpha-dimethylbutyryl-S-methyl-3-mercaptopropionate (DMB-S-MMP) as the thioester acyl donor. Has broad substrate specificity and can utilize a variety of acyl donors and monacolin analogs (in vitro). Has much higher activity with LovF-bound 2-methylbutyrate than with free diketide substrates. Can also catalyze the reverse reaction and function as hydrolase (in vitro).

Acyltransferase mlcH

Also known as Acyltransferase mlcH (Compactin biosynthesis protein H).
Compactin diketide synthase; part of the gene cluster that mediates the biosynthesis of ML-236B, also known as compactin, and which acts as a potent competitive inhibitor of HMG-CoA reductase (PubMed:12172803). Compactin biosynthesis is performed in two stages (PubMed:12172803). The first stage is catalyzed by the nonaketide synthase mlcA, which belongs to type I polyketide synthases and catalyzes the iterative nine-step formation of the polyketide (PubMed:12172803). This PKS stage completed by the action of deshydrogenase mlcG, which catalyzes the NADPH-dependent reduction of the unsaturated tetra-, penta- and heptaketide intermediates that arise during the mokA-mediated biosynthesis of the nonaketide chain and leads to dihydroML-236B (PubMed:12172803). Covalently bound dihydroML-236B is released from mlcA by the mlcF esterase (PubMed:12172803). Conversion of dihydroML-236B into ML-236C and then ML-236A is subsequently performed with the participation of molecular oxygen and P450 monoogygenase mlcC (PubMed:12172803). Finally, mlcH performs the conversion of ML-236A to ML-236B/compactin through the addition of the side-chain diketide moiety produced by the diketide synthase mlcB (PubMed:12172803).

Acyltransferase mokF

Also known as Acyltransferase mokF (Lovastatin hydrolase) (Monacolin K biosynthesis protein F).
Acyltransferase; part of the gene cluster that mediates the biosynthesis of monakolin K, also known as lovastatin, and which acts as a potent competitive inhibitor of HMG-CoA reductase (PubMed:18578535). Monakolin K biosynthesis is performed in two stages (PubMed:19693441). The first stage is catalyzed by the nonaketide synthase mokA, which belongs to type I polyketide synthases and catalyzes the iterative nine-step formation of the polyketide (PubMed:18578535, PubMed:19693441). This PKS stage is completed by the action of deshydrogenase mokE, which catalyzes the NADPH-dependent reduction of the unsaturated tetra-, penta- and heptaketide intermediates that arise during the mokA-mediated biosynthesis of the nonaketide chain and leads to dihydromonacolin L (PubMed:19693441). Covalently bound dihydromonacolin L is released from mokA by the mokD esterase (). Conversion of dihydromonacolin L into monacolin L and then monacolin J is subsequently performed with the participation of molecular oxygen and P450 monoogygenase mokC (PubMed:19693441). Finally, mokF performs the conversion of monacoline J to monacoline K through the addition of the side-chain diketide moiety (2R)-2-methylbutyric acid produced by the diketide synthase mokB (PubMed:19693441).

Acyltransferase papA1

Also known as Acyltransferase papA1 (Polyketide synthase-associated protein A1).
Catalyzes an acylation step during the biosynthesis of a cell wall sulfolipid.

Acyltransferase papA2

Also known as Acyltransferase papA2 (Polyketide synthase-associated protein A2).
Catalyzes an acylation step during the biosynthesis of a cell wall sulfolipid.

Acyltransferase papA3

Also known as Acyltransferase papA3 (Polyketide synthase-associated protein A3).
Involved in the biosynthesis of polyacyltrehalose (PAT) which could have a role in anchoring the bacterial capsule. In vitro catalyzes the sequential transfer of two palmitoyl groups onto a single glucose residue of trehalose generating the diacylated product 2,3-diacyltrehalose (trehalose dipalmitate). Although palmitoyl-CoA (PCoA) seems to be the physiological acyl donor, PapA3 can also use docosanoyl (22-carbon saturated fatty acid) coenzyme A as acyl donor.

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