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Adenomatous polyposis coli protein

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization (By similarity).

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Adenomatous polyposis coli protein

Also known as Adenomatous polyposis coli protein (Protein APC).
APC: a tumor suppressor. Defects in APC are a cause of familial adenomatous polyposis (FAP). Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. Activity is correlated with its phosphorylation state. Two splice-variant isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Tumor suppressor

Cellular Component: axon; beta-catenin destruction complex; catenin complex; cell cortex; cell projection; cell projection membrane; cell soma; cell-cell adherens junction; centrosome; cytoplasm; cytoplasmic microtubule; dendrite; growth cone; kinetochore; lamellipodium; lateral plasma membrane; microtubule; neuron projection; nuclear membrane; nucleus; plasma membrane; protein complex; synapse; tight junction

Molecular Function: beta-catenin binding; cadherin binding; gamma-catenin binding; microtubule binding; microtubule plus-end binding; protease binding; protein binding; protein complex binding; protein kinase binding; protein kinase regulator activity

Biological Process: anterior/posterior pattern formation; axis specification; axonogenesis; cell cycle arrest; cell fate specification; cell migration; cell proliferation; chromosome organization and biogenesis; cytokinesis after mitosis; cytoplasmic microtubule organization and biogenesis; dorsal/ventral pattern formation; establishment and/or maintenance of cell polarity; hair follicle development; kidney development; mitotic cell cycle spindle assembly checkpoint; mitotic metaphase/anaphase transition; muscle maintenance; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of epithelial cell proliferation; negative regulation of MAPKKK cascade; negative regulation of microtubule depolymerization; negative regulation of odontogenesis; negative regulation of Wnt receptor signaling pathway; neurite development; pancreas development; pattern specification process; positive regulation of apoptosis; positive regulation of cell adhesion; positive regulation of cell differentiation; positive regulation of cell division; positive regulation of cell migration; positive regulation of epithelial cell differentiation; positive regulation of microtubule polymerization; positive regulation of protein catabolic process; positive regulation of pseudopodium formation; protein complex assembly; proximal/distal pattern formation; regulation of attachment of spindle microtubules to kinetochore; regulation of cell cycle; regulation of cell differentiation; regulation of cell migration; regulation of epithelial cell differentiation; regulation of microtubule-based process; regulation of nitrogen compound metabolic process; regulation of osteoblast differentiation; regulation of osteoclast differentiation; response to DNA damage stimulus; response to drug; retina development in camera-type eye; skin development; somatic stem cell maintenance; stem cell maintenance; T cell differentiation in the thymus; thymus development; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin

Adenomatous polyposis coli protein 2

APCL: Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling. Belongs to the adenomatous polyposis coli (APC) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, peripheral

Cellular Component: actin filament; beta-catenin destruction complex; catenin complex; cytoplasm; cytoplasmic microtubule; Golgi apparatus; microtubule cytoskeleton; perinuclear region of cytoplasm

Molecular Function: beta-catenin binding; gamma-catenin binding

Biological Process: cell fate specification; cell migration; cell proliferation; negative regulation of microtubule depolymerization; pattern specification process; positive regulation of protein catabolic process; regulation of cell differentiation

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