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Adenosine receptor

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

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Adenosine receptor A1

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Adenosine receptor A2a

ADORA2A: one of several receptor subtypes for adenosine. A G-protein coupled receptor. Activation is mediated by G proteins which activate adenylyl cyclase. Abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: asymmetric synapse; axolemma; axon; cell soma; dendrite; endomembrane system; Golgi membrane; integral to plasma membrane; intermediate filament; membrane; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic active zone; presynaptic membrane

Molecular Function: adenosine receptor activity, G-protein coupled; alpha-actinin binding; enzyme binding; identical protein binding; protein binding; protein heterodimerization activity; type 5 metabotropic glutamate receptor binding

Biological Process: adenosine receptor signaling pathway; adenylate cyclase activation; astrocyte activation; eating behavior; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase activating pathway; locomotory behavior; membrane depolarization; negative regulation of alpha-beta T cell activation; negative regulation of caspase activity; negative regulation of cell proliferation; negative regulation of inflammatory response; negative regulation of locomotion; negative regulation of neuron apoptosis; negative regulation of protein kinase activity; negative regulation of vascular permeability; neurite morphogenesis; positive regulation of acetylcholine secretion; positive regulation of cAMP biosynthetic process; positive regulation of circadian sleep/wake cycle, sleep; positive regulation of glutamate secretion; positive regulation of protein secretion; positive regulation of synaptic transmission, GABAergic; positive regulation of synaptic transmission, glutamatergic; prepulse inhibition; protein kinase C activation; regulation of calcium ion transport; regulation of excitatory postsynaptic membrane potential; regulation of inhibitory postsynaptic membrane potential; regulation of mitochondrial membrane potential; regulation of norepinephrine secretion; regulation of synaptic plasticity; regulation of transcription, DNA-dependent; response to alkaloid; response to amphetamine; response to caffeine; response to drug; synaptic transmission, cholinergic; synaptic transmission, dopaminergic; synaptic transmission, glutamatergic; vasodilation

Adenosine receptor A2b

ADORA2B: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: cell surface; plasma membrane

Molecular Function: adenosine receptor activity, G-protein coupled; G-protein coupled receptor activity

Biological Process: cellular response to extracellular stimulus; G-protein signaling, adenylate cyclase activating pathway; negative regulation of cell proliferation; negative regulation of collagen biosynthetic process; positive regulation of cAMP biosynthetic process; positive regulation of catecholamine secretion; positive regulation of cell proliferation; positive regulation of cGMP biosynthetic process; positive regulation of chemokine production; positive regulation of chronic inflammatory response to non-antigenic stimulus; positive regulation of guanylate cyclase activity; positive regulation of interleukin-6 production; positive regulation of mast cell degranulation; positive regulation of vasodilation; regulation of angiogenesis; relaxation of vascular smooth muscle

Adenosine receptor A3

This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors involved in a variety of intracellular signaling pathways and physiological functions. Studies of orthologous proteins suggest that the receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it may have neuroprotective and neurodegenerative effects, and it may also mediate cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:104564307, which encodes a transmembrane and immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]
Proteins Root Name Listing
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