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Adenylate kinase

CATALYTIC ACTIVITY: ATP + AMP = 2 ADP.

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Adenylate kinase 1

Also known as Adenylate kinase 1 (AK 1) (ATP-AMP transphosphorylase 1) (ATP:AMP phosphotransferase 1) (Adenylate monophosphate kinase 1).
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.

Adenylate kinase 2

Also known as Adenylate kinase 2 (AK 2) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase 2) (Adenylate monophosphate kinase 2).
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.

Adenylate kinase 3

Also known as Adenylate kinase 3 (AK 3) (ATP-AMP transphosphorylase 3) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase 3) (AMK3).
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.

Adenylate kinase 4

Also known as Adenylate kinase 4 (AK 4) (ATP-AMP transphosphorylase 4) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase 4) (AMK4).
encodes a protein similar to adenylate kinase.

Adenylate kinase 5

Also known as Adenylate kinase 5, chloroplastic (ATP-AMP transphosphorylase 5) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase 5) (AMK5).
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.

Adenylate kinase 7

Also known as Adenylate kinase 7 (AK 7) (ATP-AMP transphosphorylase 7).
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function.

Adenylate kinase 8

Also known as Adenylate kinase 8 (AK 8) (ATP-AMP transphosphorylase 8).
AK8: Adenylate kinase. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Belongs to the adenylate kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.4.3; EC 2.7.4.6; Kinase, other; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q34.13

Cellular Component: cytosol

Molecular Function: adenylate kinase activity; cytidylate kinase activity; nucleoside diphosphate kinase activity; nucleoside kinase activity; protein binding

Biological Process: nucleobase, nucleoside and nucleotide interconversion; nucleoside diphosphate phosphorylation; nucleoside triphosphate biosynthetic process

Adenylate kinase 9

Also known as Adenylate kinase 9 (AK 9) (Adenylate kinase domain-containing protein 1) (Adenylate kinase domain-containing protein 2).
The protein encoded by this gene catalyzes the interconversion of nucleosides, possessing both nucleoside monophosphate and diphosphate kinase activities. The encoded protein uses these interconversions to maintain nucleoside homeostasis. [provided by RefSeq, Jul 2016]

Adenylate kinase isoenzyme 1

Also known as Adenylate kinase isoenzyme 1 (AK 1) (ATP-AMP transphosphorylase 1) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) (Myokinase).
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.

Adenylate kinase isoenzyme 5

Also known as Adenylate kinase isoenzyme 5 (AK 5) (ATP-AMP transphosphorylase 5).
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.

Adenylate kinase isoenzyme 6

Also known as Adenylate kinase isoenzyme 6 (AK6) (Adrenal gland protein AD-004) (Coilin-interacting nuclear ATPase protein) (hCINAP) (Dual activity adenylate kinase/ATPase) (AK/ATPase).
AK6: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation. {ECO:0000269|PubMed:15630091}. Belongs to the adenylate kinase family. AK6 subfamily. {ECO:0000255|HAMAP-Rule:MF_03173}. Monomer and homodimer. Interacts with COIL (via C-terminus). {ECO:0000255|HAMAP-Rule:MF_03173, ECO:0000269|PubMed:15213396, ECO:0000269|PubMed:16079131, ECO:0000269|PubMed:22038794}. 2 isoforms of the human protein are produced by alternative splicing

Protein type: Acetyltransferase; DNA-binding; EC 2.7.4.3; Kinase, other

Chromosomal Location of Human Ortholog: 5q13.2

Cellular Component: Cajal body; membrane; nucleolus; nucleoplasm

Molecular Function: adenylate kinase activity; nucleoside phosphate kinase activity; protein binding

Biological Process: nucleobase, nucleoside and nucleotide interconversion

Adenylate kinase isoenzyme 6 homolog

Also known as Adenylate kinase isoenzyme 6 homolog (AK6) (Adrenal gland protein AD-004 like protein) (ADLP) (Dual activity adenylate kinase/ATPase) (AK/ATPase).
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates. ATP and dATP are the best phosphate donors. May have a role in nuclear energy homeostasis.

Adenylate kinase isoenzyme 6 homolog FAP7

Also known as Adenylate kinase isoenzyme 6 homolog FAP7 (AK6) (Dual activity adenylate kinase/ATPase) (AK/ATPase) (POS9-activating factor 7).
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity (). Involved in 18S rRNA maturation. Required for cleavage of the 20S pre-rRNA at site D in the cytoplasm. Involved in oxidative stress response. Required for POS9-dependent target gene transcription upon oxidative stress.

Adenylate kinase isoenzyme 6 homolog HBR1

Also known as Adenylate kinase isoenzyme 6 homolog HBR1 (AK6) (Dual activity adenylate kinase/ATPase) (AK/ATPase) (Hemoglobin and proliferation-regulated protein 1) (Hb-regulated protein 1).
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation (). Induces transcription of mating-type proteins ALPHA1 and ALPHA2 and moderately represses transcription of mating-type protein A1 in response to hemoglobin and growth signals. Involved in the induction of a high affinity fibronectin receptor by sub-inhibitory dosages of caspofungin.

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