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Adipogenesis regulatory factor

Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin.

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Adipogenesis regulatory factor

Also known as Adipogenesis regulatory factor (Adipogenesis factor rich in obesity) (Adipose most abundant gene transcript 2 protein) (Adipose-specific protein 2) (apM-2).
ADIRF: Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin. Up-regulated during pre-adipocyte differentiation. Up- regulated following DNA damage induced by UV irradiation

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 10q23.2

Cellular Component: cytoplasm; nucleoplasm; nucleus

Biological Process: positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter

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