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ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for calcium mobilization from endoplasmic reticulum. Also has cADPr hydrolase activity.

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ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Also known as ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (AD.
CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cell cycle regulation; Cell surface; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.4.99.20; EC 3.2.2.6; Hydrolase; Lyase; Membrane protein, integral

Cellular Component: cell surface; intracellular membrane-bound organelle; membrane; nucleus; plasma membrane

Molecular Function: hydrolase activity, acting on glycosyl bonds; NAD+ nucleosidase activity; phosphorus-oxygen lyase activity

Biological Process: B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; negative regulation of apoptosis; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; positive regulation of B cell proliferation; positive regulation of cell growth; positive regulation of insulin secretion; positive regulation of transcription, DNA-dependent; positive regulation of vasoconstriction; response to drug; response to hormone stimulus; response to hydroperoxide; response to hypoxia

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

Also known as ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (ADP-ribosyl cyclase 2) (Antigen BP3) (BP-3 alloantigen) (Bone marrow stromal antigen 1) (BST-1) (Cyclic ADP-ribose hydrolase 2) (cADPr hydrolase 2) (Leukocyte antigen 65) (Ly-65) (CD antigen.
BST1: Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth. Belongs to the ADP-ribosyl cyclase family.

Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 3.2.2.6; Hydrolase; Membrane protein, GPI anchor

Cellular Component: plasma membrane

Molecular Function: NAD+ nucleosidase activity; phosphorus-oxygen lyase activity

Biological Process: positive regulation of B cell proliferation

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