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ADP-ribosylation factor

GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

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ADP-ribosylation factor 1

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

ADP-ribosylation factor 1-like 1

Also known as ADP-ribosylation factor 1-like 1 (ADP-ribosylation factor-like protein 6) (ADP-ribosylation factor-related protein 1.1).
GTP-binding protein that may be involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

ADP-ribosylation factor 1-like 2

Also known as ADP-ribosylation factor 1-like 2 (ADP-ribosylation factor-related protein 1.2).
GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Involved in endoplasmic reticulum dynamics during embryogenesis (PubMed:15716356). Also required for adult germline function (PubMed:15576487). Plays a role in cell shedding during embryogenesis probably by promoting the endocytosis of cell adhesion molecules (PubMed:22801495).

ADP-ribosylation factor 2-A

Also known as ADP-ribosylation factor 2-A (AtARF2).
A member of ARF GTPase family. A thaliana has 21 members of this family, known to be essential for vesicle coating and uncoating and functions in GTP-binding. Gene encoding ADP-ribosylation factor and similar to other ARFs and ARF-like proteins. The gene is shown to play a role in cell division, cell expansion and cellulose production using antisense construct.

ADP-ribosylation factor 2-B

Also known as ADP-ribosylation factor 2-B (AtARF2) (ARF1-like protein U5).
A member of ARF GTPase family. A thaliana has 21 members of this family, known to be essential for vesicle coating and uncoating and functions in GTP-binding. Gene encoding ADP-ribosylation factor and similar to other ARFs and ARF-like proteins. The gene is shown to play a role in cell division, cell expansion and cellulose production using antisense construct.

ADP-ribosylation factor 3

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus ().

ADP-ribosylation factor 4

ARF4: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Belongs to the small GTPase superfamily. Arf family.

Protein type: G protein; G protein, monomeric; G protein, monomeric, ARF; Motility/polarity/chemotaxis

Cellular Component: cytoplasm; cytosol; dendritic spine; Golgi apparatus; membrane; plasma membrane

Molecular Function: epidermal growth factor receptor binding; GTP binding

Biological Process: apical protein localization; brain development; cell migration; epidermal growth factor receptor signaling pathway; establishment and/or maintenance of epithelial cell polarity; learning; negative regulation of apoptosis; phospholipase D activation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid ADP-ribosylation; response to axon injury; retrograde vesicle-mediated transport, Golgi to ER

ADP-ribosylation factor 5

ARF5: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Belongs to the small GTPase superfamily. Arf family.

Protein type: G protein; G protein, monomeric; G protein, monomeric, ARF; Motility/polarity/chemotaxis

Cellular Component: cytoplasm; plasma membrane

Biological Process: retrograde vesicle-mediated transport, Golgi to ER

ADP-ribosylation factor 6

GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development ().
Proteins Root Name Listing
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