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ADP-ribosylation factor-like protein

GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

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ADP-ribosylation factor-like protein 13A

ARL13A: Belongs to the small GTPase superfamily. Arf family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein, monomeric; G protein, monomeric, ARF

Chromosomal Location of Human Ortholog: Xq22.1

ADP-ribosylation factor-like protein 13B

Also known as ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 13).
Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. Required for normal sensory cilium function. May act by maintaining the association between IFT subcomplexes A and B.

ADP-ribosylation factor-like protein 14

Also known as ADP-ribosylation factor-like protein 14 (ADP-ribosylation factor 7).
ARL14: GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. Belongs to the small GTPase superfamily. Arf family.

Protein type: G protein, monomeric; G protein, monomeric, ARF; Motility/polarity/chemotaxis

ADP-ribosylation factor-like protein 16

ARL16: Belongs to the small GTPase superfamily. Arf family.

Protein type: G protein, monomeric; G protein, monomeric, ARF

Chromosomal Location of Human Ortholog: 17q25.3

Molecular Function: protein binding

ADP-ribosylation factor-like protein 17

Also known as ADP-ribosylation factor-like protein 17 (ADP-ribosylation factor 7 variant).
ARL17: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Belongs to the small GTPase superfamily. Arf family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein, monomeric; G protein, monomeric, ARF

Chromosomal Location of Human Ortholog: 17q21.31

ADP-ribosylation factor-like protein 2

ARL2: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. Belongs to the small GTPase superfamily. Arf family.

Protein type: G protein, monomeric; G protein, monomeric, ARF; Mitochondrial

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: centrosome; cilium; cytosol; lateral plasma membrane; mitochondrial intermembrane space; mitochondrial matrix; nucleus

Molecular Function: GTP binding; GTPase activity; GTPase inhibitor activity; protein binding

Biological Process: centrosome organization and biogenesis; maintenance of protein localization in nucleus; positive regulation of microtubule polymerization; regulation of insulin secretion; regulation of microtubule polymerization; tubulin folding

ADP-ribosylation factor-like protein 3

ARL3: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Does not act as an allosteric activator of the cholera toxin catalytic subunit. Belongs to the small GTPase superfamily. Arf family.

Protein type: Cell cycle regulation; Cytoskeletal; G protein, monomeric; G protein, monomeric, ARF

Chromosomal Location of Human Ortholog: 10q23.3

Cellular Component: centrosome; cilium; cytoplasmic microtubule; Golgi apparatus; midbody; nucleus; photoreceptor connecting cilium; spindle microtubule

Molecular Function: GDP binding; GTP binding; microtubule binding; protein binding

Biological Process: cytokinesis; kidney development; photoreceptor cell development; post-Golgi vesicle-mediated transport; small GTPase mediated signal transduction

ADP-ribosylation factor-like protein 4A

ARL4A: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form. Belongs to the small GTPase superfamily. Arf family.

Protein type: G protein, monomeric; G protein, monomeric, ARF; Nucleolus

Chromosomal Location of Human Ortholog: 7p21.3

Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus; plasma membrane

Molecular Function: GTP binding; protein binding

ADP-ribosylation factor-like protein 4C

Also known as ADP-ribosylation factor-like protein 4C (ADP-ribosylation factor-like 7).
ARL4C: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP- bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process. Belongs to the small GTPase superfamily. Arf family.

Protein type: G protein; G protein, monomeric; G protein, monomeric, ARF

Cellular Component: cytoplasm; plasma membrane

Molecular Function: alpha-tubulin binding

Biological Process: endocytic recycling

ADP-ribosylation factor-like protein 4D

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form ().

ADP-ribosylation factor-like protein 5

GTP-binding protein that may be involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (). Plays a role in the shedding of pathogen spores from intestinal cells (PubMed:24843160).

ADP-ribosylation factor-like protein 5B

Also known as ADP-ribosylation factor-like protein 5B (ADP-ribosylation factor-like protein 8).
ARL5B: Binds and exchanges GTP and GDP. Belongs to the small GTPase superfamily. Arf family.

Protein type: G protein, monomeric; G protein, monomeric, ARF

ADP-ribosylation factor-like protein 5C

Also known as ADP-ribosylation factor-like protein 5C (ADP-ribosylation factor-like protein 12).
ARL5C: Binds and exchanges GTP and GDP. Belongs to the small GTPase superfamily. Arf family.

Protein type: G protein, monomeric; G protein, monomeric, ARF

ADP-ribosylation factor-like protein 8B

ARL8B: May play a role in lysosome motility (PubMed:16537643). May play a role in chromosome segregation (PubMed:15331635). Belongs to the small GTPase superfamily. Arf family.

Protein type: G protein, monomeric; G protein, monomeric, ARF

Cellular Component: cytoplasm; lysosomal membrane; membrane; midbody; spindle midzone

Molecular Function: alpha-tubulin binding; beta-tubulin binding; GDP binding; GTP binding

Biological Process: chromosome segregation; lysosome localization

ADP-ribosylation factor-like protein 9

ARL9: Belongs to the small GTPase superfamily. Arf family

Protein type: G protein, monomeric; G protein, monomeric, ARF

Chromosomal Location of Human Ortholog: 4q12
Proteins Root Name Listing
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