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ADP-ribosylation factor-like protein 6-interacting protein

Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity). Plays a role in the formation and stabilization of endoplasmic reticulum tubules .

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ADP-ribosylation factor-like protein 6-interacting protein 1

Also known as ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL-6-interacting protein 1) (Aip-1) (Apoptotic regulator in the membrane of the endoplasmic reticulum).
ARL6IP: May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Belongs to the ARL6ip family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16p12-p11.2

Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; integral to membrane; membrane; translocon complex

Molecular Function: identical protein binding; protein binding

Biological Process: cotranslational protein targeting to membrane; negative regulation of apoptosis; negative regulation of caspase activity; positive regulation of L-glutamate transport

Disease: Spastic Paraplegia 61, Autosomal Recessive

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