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ADP-sugar pyrophosphatase

Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (By similarity). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP .

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ADP-sugar pyrophosphatase

Also known as ADP-sugar pyrophosphatase (8-oxo-dGDP phosphatase) (Nuclear ATP-synthesis protein NUDIX5) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5).
NUDT5: Hydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Belongs to the Nudix hydrolase family.

Protein type: EC 3.6.1.13; EC 3.6.1.58; Nucleotide Metabolism - purine; Phosphatase

Cellular Component: nucleus

Molecular Function: ADP-ribose diphosphatase activity; ADP-sugar diphosphatase activity; m7G(5')pppN diphosphatase activity; magnesium ion binding; nucleoside-diphosphatase activity; nucleotidyltransferase activity; protein homodimerization activity; snoRNA binding

Biological Process: chromatin remodeling; D-ribose catabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; ribonucleoside diphosphate catabolic process

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