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Adrenocortical dysplasia protein

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity (By similarity). May play a role in organogenesis .

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Adrenocortical dysplasia protein

ACD: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleoplasm; nucleus

Molecular Function: protein binding; telomeric DNA binding

Biological Process: embryonic limb morphogenesis; intracellular protein transport; negative regulation of telomere maintenance via telomerase; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protection from non-homologous end joining at telomere; segmentation; skeletal development; telomere assembly; telomere capping; telomere maintenance; urogenital system development

Adrenocortical dysplasia protein homolog

ACD: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleoplasm; nucleus

Molecular Function: telomeric DNA binding

Biological Process: embryonic limb morphogenesis; intracellular protein transport; negative regulation of telomere maintenance via telomerase; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protection from non-homologous end joining at telomere; segmentation; skeletal development; telomere assembly; telomere capping; telomere maintenance; urogenital system development
Proteins Root Name Listing
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