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AF4/FMR2 family

Below are the list of possible AF4/FMR2 family products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the reer's specifications.

AF4/FMR2 family member 1

Also known as AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4).
AF-4: A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with MLL/HRX. The result is a rogue activator protein. Belongs to the AF4 family.

Protein type: Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: transcription elongation factor complex

Molecular Function: protein binding; transcription factor activity

AF4/FMR2 family member 2

Also known as AF4/FMR2 family member 2 (FMR2P) (Fragile X mental retardation protein 2 homolog) (Protein FMR-2) (Protein Ox19).
AFF2: RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure. Defects in AFF2 are the cause of mental retardation X- linked associated with fragile site FRAXE (MRFRAXE). A form of mild to moderate mental retardation associated with learning difficulties, communication deficits, attention problems, hyperactivity, and autistic behavior. It is associated with a fragile site on chromosome Xq28. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Caused either by silencing of the AFF2 gene as a consequence of a CCG expansion located upstream of this gene or by deletion within the gene. Loss of AFF2 expression is correlated with FRAXE CCG(N) expansion. Normal individuals have 6-35 copies of the repeat, whereas cytogenetically positive, developmentally delayed males have more than 200 copies and show methylation of the associated CPG island. Belongs to the AF4 family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Cellular Component: nuclear speck

Biological Process: learning and/or memory; regulation of RNA splicing

AF4/FMR2 family member 3

Also known as AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4).
AFF3: Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double- stranded DNA. Belongs to the AF4 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 2q11.2-q12

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: double-stranded DNA binding

Biological Process: embryonic hindlimb morphogenesis

AF4/FMR2 family member 4

MCEF: a putative transcription factor. Component of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor b (P-TEFb). Genetic fusion of its gene with MLL has been observed in a subset of acute lymphoblastic leukemia patients. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Transcription factor

Cellular Component: nucleus; transcription elongation factor complex

Molecular Function: protein binding

Biological Process: spermatid development

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