Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm.
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Afadin: plays a role in adhesion by participating, along with E-cadherin and catenin, in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Essential for the association of nectin and E-cadherin. Contains 1 forkhead-associated (FHA) domain, a phosphopeptide recognition domain; 1 dilute (DIL) domain, a myosin-like domain which may play a functional role in cellular processes or vectorial vesicle transport; 1 PDZ domain, which frequently binds the carboxyl-terminal sequences of proteins or phosphatidylinositol 4,5-bisphosphate in the plasma membrane; and 2 RA domains, which are associated with RasGTP effector activity. Five alternatively spliced isoforms have been described. Isoform 2 does not interact with F-actin.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Oncoprotein
Cellular Component: adherens junction; apical junction complex; apical part of cell; cell junction; cell-cell adherens junction; cytoplasm; intercellular junction; nucleoplasm; plasma membrane
Molecular Function: cell adhesion molecule binding; LIM domain binding; protein binding; Ras GTPase binding
Biological Process: brain morphogenesis; cerebral cortex development; homeostasis of number of cells; positive regulation of GTPase activity; radial glial cell differentiation; telencephalon development
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