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Aflatoxin B1 aldehyde reductase

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

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Aflatoxin B1 aldehyde reductase member 2

Also known as Aflatoxin B1 aldehyde reductase member 2 (AFB1 aldehyde reductase 1) (AFB1-AR 1) (Aldoketoreductase 7) (Succinic semialdehyde reductase) (SSA reductase).
AKR7A2: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2- nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.

Protein type: EC 1.1.1.n11; Oxidoreductase

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: cytosol

Molecular Function: aldehyde reductase activity; aldo-keto reductase activity; electron carrier activity; phenanthrene-9,10-epoxide hydrolase activity; protein binding

Biological Process: aldehyde metabolic process; carbohydrate metabolic process; xenobiotic metabolic process

Aflatoxin B1 aldehyde reductase member 3

Also known as Aflatoxin B1 aldehyde reductase member 3 (AFB1 aldehyde reductase 2) (AFB1-AR 2).
AKR7A3: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.

Protein type: EC 1.-.-.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: cytosol

Molecular Function: aldo-keto reductase activity; electron carrier activity; identical protein binding; protein binding

Biological Process: aldehyde metabolic process; xenobiotic metabolic process

Aflatoxin B1 aldehyde reductase member 4

Also known as Aflatoxin B1 aldehyde reductase member 4 (AFB1 aldehyde reductase 3) (AFB1-AR 3) (Aldoketoreductase 7-like).
AKR7A4: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.-.-.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 1p36.13|1p35-p36.1

Cellular Component: cytosol

Molecular Function: aldo-keto reductase activity

Biological Process: xenobiotic metabolic process

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