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Agouti-signaling protein

Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). Causes hair follicle melanocytes to synthesize phaeomelanin instead of black or brown pigment eumelanin and produces hairs with a subapical yellow band on an otherwise black or brown background when expressed during the mid-portion of hair growth.

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Agouti-signaling protein

Also known as Agouti-signaling protein (ASP) (Agouti coat color protein) (Agouti switch protein).
ASIP: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.

Protein type: Secreted; Secreted, signal peptide

Molecular Function: melanocortin receptor binding; protein binding; type 3 melanocortin receptor binding; type 4 melanocortin receptor binding

Biological Process: adult feeding behavior; generation of precursor metabolites and energy; melanin biosynthetic process; melanosome organization and biogenesis; melanosome transport; pigmentation; positive regulation of melanin biosynthetic process; regulation of molecular function, epigenetic
Proteins Root Name Listing
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