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Akirin

Required for embryonic development and for normal innate immune response. Effector of immune deficiency pathway (Imd) acting either downstream of, or at the level of, the NF-kappa-B factor Relish (Rel). Not part of the Toll pathway.

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Akirin

Also known as Akirin (Protein bhringi).
Required for embryonic development and for normal innate immune response. Effector of immune deficiency pathway (Imd) acting either downstream of, or at the level of, the NF-kappa-B factor Relish (Rel). Not part of the Toll pathway.

Akirin-1

AKIRIN1: Belongs to the akirin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription regulation

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: nuclear membrane; nucleoplasm; nucleus

Molecular Function: protein binding

Akirin-2

AKIRIN2: Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1. Belongs to the akirin family.

Protein type: Cell cycle regulation; Transcription regulation

Chromosomal Location of Human Ortholog: 6q15

Cellular Component: nucleus; transcriptional repressor complex

Molecular Function: enzyme binding; protein binding

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