• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

AKT-interacting protein

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.

Below are the list of possible AKT-interacting protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the reer's specifications.

AKT-interacting protein

Also known as AKT-interacting protein (Ft1) (Fused toes protein homolog).
AKTIP: an oncogenic membrane-associated protein that is a component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with HOOK1, HOOK2 and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex). Apparently interacts with AKT1. A member of the ubiquitin-conjugating enzyme family, FTS subfamily. Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, peripheral; Vesicle

Chromosomal Location of Human Ortholog: 16q12.2

Cellular Component: cytoplasm; Golgi apparatus; nucleolus; plasma membrane

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: early endosome to late endosome transport; endosome organization and biogenesis; endosome to lysosome transport; lysosome organization and biogenesis; positive regulation of protein amino acid phosphorylation; positive regulation of protein binding

Go back to Proteins Root Name Listing
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000