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Aldo-keto reductase family

Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.

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Aldo-keto reductase family 1 member B10

Also known as Aldo-keto reductase family 1 member B10 (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase).
AKR1B10: Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. Belongs to the aldo/keto reductase family.

Protein type: Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - fructose and mannose; EC 1.1.1.-; EC 1.1.1.21; Lipid Metabolism - linoleic acid; Oxidoreductase

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: cytosol

Molecular Function: aldo-keto reductase activity; geranylgeranyl reductase activity; indanol dehydrogenase activity; protein binding; retinal dehydrogenase activity

Biological Process: aldehyde metabolic process; digestion; farnesol catabolic process; retinoid metabolic process; steroid metabolic process

Aldo-keto reductase family 1 member B15

Also known as Aldo-keto reductase family 1 member B15 (Estradiol 17-beta-dehydrogenase AKR1B15).
AKR1B15: Possesses weak oxidoreductase activity. Belongs to the aldo/keto reductase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.1.1.-; EC 1.1.1.21; EC 1.1.1.62; Oxidoreductase

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: mitochondrial matrix

Molecular Function: estradiol 17-beta-dehydrogenase activity

Biological Process: estrogen biosynthetic process

Aldo-keto reductase family 1 member C1

Also known as Aldo-keto reductase family 1 member C1 (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1/2) (DD1/DD2) (High-affinity hepatic bile acid-binding protein) (HB.
AKR1C1: Converts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation. Belongs to the aldo/keto reductase family.

Protein type: EC 1.1.1.112; EC 1.1.1.149; EC 1.3.1.20; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450

Chromosomal Location of Human Ortholog: 10p15-p14

Cellular Component: cytosol

Molecular Function: 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity; aldehyde reductase activity; aldo-keto reductase activity; bile acid binding; carboxylic acid binding; ketosteroid monooxygenase activity; oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; phenanthrene 9,10-monooxygenase activity; protein binding; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

Biological Process: bile acid and bile salt transport; bile acid metabolic process; cholesterol absorption; cholesterol homeostasis; digestion; epithelial cell differentiation; progesterone metabolic process; protein homooligomerization; response to organophosphorus; retinal metabolic process; retinoid metabolic process

Aldo-keto reductase family 1 member C1 homolog

Also known as Aldo-keto reductase family 1 member C1 homolog (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (Dihydrodiol dehydrogenase 1) (DD-1) (DD1) (Indanol dehydrogenase).
Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. May play a role in myelin formation. Can oxidize both 20-alpha- and 3-alpha-hydroxysteroids.

Aldo-keto reductase family 1 member C13

AKR1C13: Belongs to the aldo/keto reductase family.

Protein type: EC 1.1.1.-; Oxidoreductase

Molecular Function: aldo-keto reductase activity

Biological Process: xenobiotic metabolic process

Aldo-keto reductase family 1 member C18

Also known as Aldo-keto reductase family 1 member C18 (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD).
AKR1C3: Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. Belongs to the aldo/keto reductase family.

Protein type: EC 1.1.1.149; Lipid Metabolism - arachidonic acid; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450

Cellular Component: cytoplasm; cytosol; intracellular; nucleus

Molecular Function: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity; 20-alpha-hydroxysteroid dehydrogenase activity; 3(or 17)-alpha-hydroxysteroid dehydrogenase activity; aldehyde reductase activity; aldo-keto reductase activity; delta4-3-oxosteroid 5beta-reductase activity; geranylgeranyl reductase activity; ketoreductase activity; ketosteroid monooxygenase activity; oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; phenanthrene 9,10-monooxygenase activity; retinal dehydrogenase activity; retinol dehydrogenase activity

Biological Process: farnesol catabolic process; G-protein coupled receptor protein signaling pathway; parturition; positive regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; progesterone catabolic process; progesterone metabolic process; protein import into nucleus, translocation; regulation of retinoic acid receptor signaling pathway; regulation of steroid biosynthetic process; retinal metabolic process

Aldo-keto reductase family 1 member C2

Also known as Aldo-keto reductase family 1 member C2 (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Trans-1,2-dihydrobenzene-1,2-diol dehydrog.
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Aldo-keto reductase family 1 member C21

Also known as Aldo-keto reductase family 1 member C21 (17-alpha-hydroxysteroid dehydrogenase) (17-alpha-HSD) (3(or 17)-alpha-hydroxysteroid dehydrogenase) (3-alpha-hydroxysteroid dehydrogenase).
AKR1C2: Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability. Defects in AKR1C2 are a cause of 46,XY sex reversal type 8 (SRXY8). A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. Belongs to the aldo/keto reductase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.1.1.357; EC 1.3.1.20; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450

Molecular Function: 3(or 17)-alpha-hydroxysteroid dehydrogenase activity; aldehyde reductase activity; bile acid binding; carboxylic acid binding; ketosteroid monooxygenase activity; oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; phenanthrene 9,10-monooxygenase activity; steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

Biological Process: digestion; epithelial cell differentiation; G-protein coupled receptor protein signaling pathway; positive regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; progesterone metabolic process; prostaglandin metabolic process; steroid metabolic process

Aldo-keto reductase family 1 member C23-like protein

Also known as Aldo-keto reductase family 1 member C23-like protein (Putative prostaglandin F synthase).
NADP-dependent oxidoreductase involved in steroid metabolism. May act on various hydroxysteroids.

Aldo-keto reductase family 1 member C3

Also known as Aldo-keto reductase family 1 member C3 (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (Chlordecone reductase homolog.
AKR1C3: Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. Belongs to the aldo/keto reductase family.

Protein type: EC 1.1.1.149; Lipid Metabolism - arachidonic acid; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450

Chromosomal Location of Human Ortholog: 10p15-p14

Cellular Component: cytoplasm; cytosol; intracellular; nucleus

Molecular Function: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity; 3(or 17)-alpha-hydroxysteroid dehydrogenase activity; aldehyde reductase activity; aldo-keto reductase activity; delta4-3-oxosteroid 5beta-reductase activity; geranylgeranyl reductase activity; ketoreductase activity; ketosteroid monooxygenase activity; oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; phenanthrene 9,10-monooxygenase activity; retinal dehydrogenase activity; retinol dehydrogenase activity

Biological Process: cellular response to starvation; cyclooxygenase pathway; farnesol catabolic process; G-protein coupled receptor protein signaling pathway; keratinocyte differentiation; male gonad development; multicellular organismal macromolecule metabolic process; positive regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; progesterone metabolic process; prostaglandin metabolic process; protein import into nucleus, translocation; regulation of retinoic acid receptor signaling pathway; response to nutrient; retinal metabolic process; retinoid metabolic process; steroid metabolic process

Aldo-keto reductase family 1 member C3 homolog

Also known as Aldo-keto reductase family 1 member C3 homolog (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (Indanol dehydrogenase) (Prostagland.
Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

Aldo-keto reductase family 1 member C4

Also known as Aldo-keto reductase family 1 member C4 (3-alpha-HSD1) (3-alpha-hydroxysteroid dehydrogenase type I) (Chlordecone reductase) (CDR) (Dihydrodiol dehydrogenase 4) (DD-4) (DD4).
Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.

Aldo-keto reductase family 4 member C9

Encodes an NADPH-dependent aldo-keto reductase that can act on a wide variety of substrates in vitro including saturated and unsaturated aldehydes, steroids, and sugars. GFP-tagged AKR4C9 localizes to the chloroplast where it may play a role in detoxifying reactive carbonyl compounds that threaten to impair the photosynthetic process. Transcript levels for this gene are up-regulated in response to cold, salt, and drought stress.
Proteins Root Name Listing
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