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Alkaline ceramidase

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.

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Alkaline ceramidase

Also known as Alkaline ceramidase (AlkCDase) (Alkaline N-acylsphingosine amidohydrolase) (Alkaline acylsphingosine deacylase).
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.

Alkaline ceramidase 1

Also known as Alkaline ceramidase 1 (AlkCDase 1) (Alkaline CDase 1) (Acylsphingosine deacylase 3) (N-acylsphingosine amidohydrolase 3).
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0.

Alkaline ceramidase 2

Also known as Alkaline ceramidase 2 (AlkCDase 2) (Alkaline CDase 2) (haCER2) (Acylsphingosine deacylase 3-like) (N-acylsphingosine amidohydrolase 3-like).
ACER2: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)- ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)- ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate. Belongs to the alkaline ceramidase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.5.1.23; Hydrolase; Lipid Metabolism - sphingolipid; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 9p22.1

Cellular Component: Golgi apparatus; Golgi membrane; integral to Golgi membrane

Molecular Function: ceramidase activity

Biological Process: caspase activation; negative regulation of cell adhesion mediated by integrin; negative regulation of cell-matrix adhesion; positive regulation of cell proliferation; response to retinoic acid; sphingolipid biosynthetic process; sphingosine biosynthetic process

Alkaline ceramidase 3

Also known as Alkaline ceramidase 3 (AlkCDase 3) (Alkaline CDase 3) (Alkaline dihydroceramidase SB89) (Alkaline phytoceramidase) (aPHC).
ACER3: Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity. Belongs to the alkaline ceramidase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.5.1.-; Hydrolase; Lipid Metabolism - sphingolipid; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q13.5

Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; integral to Golgi membrane

Biological Process: positive regulation of cell proliferation; sphingolipid biosynthetic process; sphingosine biosynthetic process

Alkaline ceramidase YDC1

Catalyzes the conversion of dihydroceramide and also phytoceramide to dihydrosphingosine or phytosphingosine. Prefers dihydroceramide. Very low reverse hydrolysis activity, catalyzing synthesis of dihydroceramide from fatty acid and dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide. May play a role in heat stress response.

Alkaline ceramidase YPC1

Hydrolyzes phytoceramide and also dihydroceramide into phytosphingosine or dihydrosphingosine. Prefers phytoceramide. Has also reverse hydrolysis activity, catalyzing synthesis of phytoceramide and dihydroceramide from palmitic acid and phytosphingosine or dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide.
Proteins Root Name Listing
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