Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway (By similarity).
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APR3: May play a critical role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. Up-regulated by all-trans-retinoic acid (ATRA) in several tumor cell lines. Weakly expressed in hematopoietic cell lines. 3 isoforms of the human protein are produced by alternative promoter.
Protein type: Membrane protein, integral
Cellular Component: lysosomal membrane; nuclear envelope; perinuclear region of cytoplasm
Biological Process: negative regulation of osteoblast proliferation; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; regulation of gene expression
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