Retinol saturase carrying out the saturation of the 13-14 double bond of all-trans-retinol to produce all-trans-13,14-dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity).
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All-trans-retinol 13,14-reductase Recombinant
All-trans-retinol 13,14-reductase Antibody
RETSAT: Retinol saturase carrying out the saturation of the 13- 14 double bond of all-trans-retinol to produce all-trans-13,14- dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A. Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cofactor and Vitamin Metabolism - retinol; EC 18.104.22.168; Nuclear envelope; Oxidoreductase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2p11.2
Cellular Component: endoplasmic reticulum membrane; membrane; nuclear membrane; nuclear outer membrane
Molecular Function: all-trans-retinol 13,14-reductase activity; oxidoreductase activity
Biological Process: retinol metabolic process