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Alpha-1-antitrypsin

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Inhibits trypsin, chymotrypsin and plasminogen activator (By similarity).

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Alpha-1-antitrypsin

Also known as Alpha-1-antitrypsin (AAT) (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1).
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Inhibits trypsin, chymotrypsin and plasminogen activator ().

Alpha-1-antitrypsin 1-1

Also known as Alpha-1-antitrypsin 1-1 (AAT) (Alpha-1 protease inhibitor 1) (Alpha-1-antiproteinase) (Serine protease inhibitor 1-1) (Serine protease inhibitor A1a) (Serpin A1a).
SERPINA1: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD). A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor; Secreted; Secreted, signal peptide

Cellular Component: endoplasmic reticulum; extracellular region; extracellular space; Golgi apparatus

Molecular Function: endopeptidase inhibitor activity; glycoprotein binding; identical protein binding; protease binding; protein binding; serine-type endopeptidase inhibitor activity

Biological Process: protein amino acid N-linked glycosylation; response to cytokine stimulus; response to peptide hormone stimulus

Alpha-1-antitrypsin 1-2

Also known as Alpha-1-antitrypsin 1-2 (AAT) (Alpha-1 protease inhibitor 2) (Alpha-1-antiproteinase) (Serine protease inhibitor 1-2) (Serine protease inhibitor A1b) (Serpin A1b).
Serpina1b:

Cellular Component: endoplasmic reticulum; extracellular region; extracellular space; Golgi apparatus

Molecular Function: endopeptidase inhibitor activity; glycoprotein binding; identical protein binding; protease binding; protein binding; serine-type endopeptidase inhibitor activity

Biological Process: in utero embryonic development; protein amino acid N-linked glycosylation; response to cytokine stimulus; response to peptide hormone stimulus

Alpha-1-antitrypsin 1-3

Also known as Alpha-1-antitrypsin 1-3 (Alpha-1 protease inhibitor 3) (Alpha-1 protease inhibitor 6) (Alpha-1-antitrypsin 1-6) (Serine protease inhibitor 1-3) (Serine protease inhibitor 1-6) (Serine protease inhibitor A1c) (Serpin A1c).
Serpina1c: Inhibitor of serine proteases. Can inhibit trypsin and chymotrypsin; relatively ineffective against elastase. Belongs to the serpin family.

Cellular Component: endoplasmic reticulum; extracellular region; extracellular space; Golgi apparatus

Molecular Function: endopeptidase inhibitor activity; glycoprotein binding; identical protein binding; protease binding; serine-type endopeptidase inhibitor activity

Biological Process: response to cytokine stimulus; response to peptide hormone stimulus

Alpha-1-antitrypsin 1-4

Also known as Alpha-1-antitrypsin 1-4 (Alpha-1 protease inhibitor 4) (Serine protease inhibitor 1-4) (Serine protease inhibitor A1d) (Serpin A1d).
Serpina1d:

Cellular Component: endoplasmic reticulum; extracellular region; extracellular space; Golgi apparatus

Molecular Function: endopeptidase inhibitor activity; glycoprotein binding; identical protein binding; protease binding; serine-type endopeptidase inhibitor activity

Biological Process: response to cytokine stimulus; response to peptide hormone stimulus

Alpha-1-antitrypsin 1-5

Also known as Alpha-1-antitrypsin 1-5 (Alpha-1 protease inhibitor 5) (Serine protease inhibitor 1-5) (Serine protease inhibitor A1e) (Serpin A1e).
Serpina1e: Does not inhibit elastase or chymotrypsin. No target protease has been identified to date. Belongs to the serpin family.

Cellular Component: endoplasmic reticulum; extracellular space; Golgi apparatus

Molecular Function: endopeptidase inhibitor activity; glycoprotein binding; identical protein binding; protease binding; serine-type endopeptidase inhibitor activity

Biological Process: response to cytokine stimulus; response to peptide hormone stimulus

Alpha-1-antitrypsin 1-6

Also known as Alpha-1-antitrypsin 1-6 (Alpha-1 protease inhibitor 6) (Alpha-1-antiproteinase) (Serine protease inhibitor 1-6) (Serine protease inhibitor A1f) (Serpin A1f).
Serpina1f:

Cellular Component: extracellular space

Molecular Function: serine-type endopeptidase inhibitor activity

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