Could inhibit both insulin-receptor tyrosine kinase activity and insulin-stimulated receptor autophosphorylation and, concomitantly, antagonize the mitogenic effect of the hormone in cultured rat hepatoma cells.
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FETUA: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions. Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond. Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins. Belongs to the fetuin family.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: extracellular matrix; extracellular space; protein complex
Molecular Function: endopeptidase inhibitor activity; receptor signaling protein tyrosine kinase inhibitor activity
Biological Process: acute-phase response; cellular response to insulin stimulus; cerebral cortex development; male gonad development; negative regulation of bone mineralization; negative regulation of cell growth; negative regulation of insulin receptor signaling pathway; organ regeneration; ossification; positive regulation of bone resorption; positive regulation of phagocytosis; protein complex assembly; regulation of inflammatory response