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Alpha-actinin

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Increases the actin-stimulated ATPase activity of myosin. Involved in vegetative cell growth, phagocytosis, motility and development, probably through stabilization of the actin network in the cortical cytoskeleton.

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Alpha-actinin A

Also known as Alpha-actinin A (Actin-binding protein A) (F-actin cross-linking protein).
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Increases the actin-stimulated ATPase activity of myosin. Involved in vegetative cell growth, phagocytosis, motility and development, probably through stabilization of the actin network in the cortical cytoskeleton.

Alpha-actinin, sarcomeric

Also known as Alpha-actinin, sarcomeric (F-actin cross-linking protein).
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein ().

Alpha-actinin-1

Also known as Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1).
ACTN1: a cytoskeletal protein of the spectrin superfamily. An actin-binding protein with multiple roles in different cell types. A nonmuscle isoform structurally similar to the erythroid beta spectrin gene.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Cellular Component: actin filament; brush border; cell projection; cortical actin cytoskeleton; cytoplasm; cytosol; dendritic spine; extracellular space; fascia adherens; focal adhesion; intercellular junction; intracellular; lamellipodium; lateral plasma membrane; leading edge; nucleus; ruffle; sarcolemma; sarcomere; stress fiber; tight junction; Z disc; zonula adherens

Molecular Function: actin filament binding; alpha-actinin binding; double-stranded RNA binding; integrin binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; protein domain specific binding; protein homodimerization activity; vinculin binding

Biological Process: actin filament bundle formation; actin filament network formation; actin filament organization; focal adhesion formation; negative regulation of cell motility; platelet activation; platelet formation; sarcomere organization; skeletal muscle fiber development

Alpha-actinin-2

Also known as Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein).
ACTN2: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Belongs to the alpha-actinin family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q42-q43

Cellular Component: actin filament; cytosol; dendritic spine; extracellular region; filopodium; focal adhesion; plasma membrane; pseudopodium; Z disc

Molecular Function: cytoskeletal protein binding; FATZ binding; identical protein binding; integrin binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein dimerization activity; protein domain specific binding; protein homodimerization activity; Ras guanyl-nucleotide exchange factor activity; structural constituent of muscle; titin binding

Biological Process: actin filament uncapping; cell adhesion; focal adhesion formation; MAPKKK cascade; microspike biogenesis; muscle filament sliding; negative regulation of potassium ion transport; platelet degranulation; positive regulation of potassium ion transport; protein homotetramerization; regulation of membrane potential; sarcomere organization

Disease: Cardiomyopathy, Dilated, 1aa

Alpha-actinin-3

Also known as Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein).
ACTN3: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Belongs to the alpha-actinin family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Cellular Component: brush border; intracellular; sarcomere; striated muscle thin filament; Z disc

Molecular Function: actin filament binding; protein binding; protein binding, bridging; protein homodimerization activity

Biological Process: muscle contraction; negative regulation of glycolysis; osteoblast differentiation; positive regulation of fast-twitch skeletal muscle contraction; positive regulation of skeletal muscle fiber development; positive regulation of skeletal muscle growth; regulation of the force of skeletal muscle contraction; response to denervation involved in regulation of muscle adaptation; skeletal muscle atrophy; transition between fast and slow fiber

Alpha-actinin-4

Also known as Alpha-actinin-4 (Non-muscle alpha-actinin 4).
ACTN4: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Defects in ACTN4 are the cause of focal segmental glomerulosclerosis type 1 (FSGS1). A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. Belongs to the alpha-actinin family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Cellular Component: actin cytoskeleton; cortical cytoskeleton; cytoplasm; cytosol; extracellular space; focal adhesion; intercellular junction; intracellular; neuron projection; nucleus; perinuclear region of cytoplasm; protein complex; pseudopodium; ribonucleoprotein complex; stress fiber; Z disc

Molecular Function: actin filament binding; chromatin DNA binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; nucleoside binding; protein binding; protein complex binding; protein homodimerization activity; protein N-terminus binding; retinoic acid receptor binding

Biological Process: actin filament bundle formation; negative regulation of cell motility; positive regulation of cell migration; positive regulation of cell motility; positive regulation of pinocytosis; regulation of apoptosis; response to hypoxia; retinoic acid receptor signaling pathway; vesicle transport along actin filament

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