Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
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ADD1: a cytoskeletal protein that promotes the assembly of the spectrin-actin network. Adducin is a heterodimeric protein that consists of related subunits. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Three alternatively-spliced isoforms have been described.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Cellular Component: cell-cell adherens junction; cytoskeleton; dendrite; dendritic spine; F-actin capping protein complex; focal adhesion; membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; synapse
Molecular Function: actin filament binding; protein heterodimerization activity; protein homodimerization activity; spectrin binding; structural molecule activity; T cell receptor binding; transcription factor binding
Biological Process: actin filament bundle formation; barbed-end actin filament capping; cell morphogenesis; cell volume homeostasis; erythrocyte differentiation; hemoglobin metabolic process; homeostasis of number of cells within a tissue; in utero embryonic development; multicellular organism growth; negative regulation of actin filament polymerization; positive regulation of angiogenesis; positive regulation of endocytosis; positive regulation of protein binding